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Anna C. Salzberg
Researcher at Pennsylvania State University
Publications - 37
Citations - 1572
Anna C. Salzberg is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 17, co-authored 36 publications receiving 1323 citations. Previous affiliations of Anna C. Salzberg include Brandeis University & Penn State Cancer Institute.
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Journal ArticleDOI
Structure-based maximal affinity model predicts small-molecule druggability.
Alan C. Cheng,Alan C. Cheng,Ryan G. Coleman,Kathleen T. Smyth,Qing Cao,Patricia Soulard,Daniel R. Caffrey,Anna C. Salzberg,Enoch S. Huang +8 more
TL;DR: It is shown that a model-based approach using basic biophysical principles yields good prediction of druggability based solely on the crystal structure of the target binding site and that these calculated values correlate with drug discovery outcomes.
Journal ArticleDOI
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead
William H. Goodson,Leroy Lowe,David O. Carpenter,Michael Gilbertson,Abdul Manaf Ali,Adela Lopez de Cerain Salsamendi,Ahmed Lasfar,Amancio Carnero,Amaya Azqueta,Amedeo Amedei,Amelia K Charles,Andrew Collins,Andrew Ward,Anna C. Salzberg,Annamaria Colacci,Ann-Karin Olsen,Arthur Berg,Barry J. Barclay,Binhua P. Zhou,Carmen Blanco-Aparicio,Carolyn J. Baglole,Chenfang Dong,Chiara Mondello,Chia-Wen Hsu,Christian C. Naus,Clement G. Yedjou,Colleen S. Curran,Dale W. Laird,Daniel C. Koch,Danielle J Carlin,Dean W. Felsher,Debasish Roy,Dustin G. Brown,Edward A. Ratovitski,Elizabeth P. Ryan,Emanuela Corsini,Emilio Rojas,Eun-Yi Moon,Ezio Laconi,Fabio Marongiu,Fahd Al-Mulla,Ferdinando Chiaradonna,Firouz Darroudi,Francis Martin,Frederik J. van Schooten,Gary S. Goldberg,Gerard Wagemaker,Gladys N. Nangami,Gloria M. Calaf,Gloria M. Calaf,Graeme Williams,Gregory T. Wolf,Gudrun Koppen,Gunnar Brunborg,H. Kim Lyerly,Harini Krishnan,Hasiah Ab Hamid,Hemad Yasaei,Hideko Sone,Hiroshi Kondoh,Hosni Salem,Hsue-Yin Hsu,Hyun Ho Park,Igor Koturbash,Isabelle R. Miousse,A. Ivana Scovassi,James E. Klaunig,Jan Vondráček,Jayadev Raju,Jesse Roman,Jesse Roman,John Pierce Wise,Jonathan Whitfield,Jordan Woodrick,Joseph Christopher,Josiah Ochieng,Juan Fernando Martinez-Leal,Judith Weisz,Julia Kravchenko,Jun Sun,Kalan R. Prudhomme,Kannan Badri Narayanan,Karine A. Cohen-Solal,Kim Moorwood,Laetitia Gonzalez,Laura Soucek,Le Jian,Leandro S. D'Abronzo,Liang Tzung Lin,Lin Li,Linda S M Gulliver,Lisa J. McCawley,Lorenzo Memeo,Louis Vermeulen,Luc Leyns,Luoping Zhang,Mahara Valverde,Mahin Khatami,Maria Romano,Marion Chapellier,Marc A. Williams,Mark Wade,Masoud H. Manjili,Matilde E. Lleonart,Menghang Xia,Michael J. Gonzalez,Michalis V. Karamouzis,Micheline Kirsch-Volders,Monica Vaccari,Nancy B. Kuemmerle,Nancy B. Kuemmerle,Neetu Singh,Nichola Cruickshanks,Nicole Kleinstreuer,Nik van Larebeke,Nuzhat Ahmed,Olugbemiga Ogunkua,Periyadan K. Krishnakumar,Pankaj Vadgama,Paola A. Marignani,Paramita M. Ghosh,Patricia Ostrosky-Wegman,Patricia A. Thompson,Paul Dent,Petr Heneberg,Philippa D. Darbre,Po Sing Leung,Pratima Nangia-Makker,Qiang Shawn Cheng,R. Brooks Robey,R. Brooks Robey,Rabeah Al-Temaimi,Rabindra Roy,Rafaela Andrade-Vieira,Ranjeet Kumar Sinha,Rekha Mehta,Renza Vento,Renza Vento,Riccardo Di Fiore,Richard Ponce-Cusi,Rita Dornetshuber-Fleiss,Rita Dornetshuber-Fleiss,Rita Nahta,Robert C. Castellino,Roberta Palorini,Roslida Abd Hamid,Sabine A. S. Langie,Sakina E. Eltom,Samira A. Brooks,Sandra Ryeom,Sandra S. Wise,Sarah N Bay,Shelley A. Harris,Shelley A. Harris,Silvana Papagerakis,Simona Romano,Sofia Pavanello,Staffan Eriksson,Stefano Forte,Stephanie C. Casey,Sudjit Luanpitpong,Tae-Jin Lee,Takemi Otsuki,Tao Chen,Thierry Massfelder,Thomas Sanderson,Tiziana Guarnieri,Tove Hultman,Valérian Dormoy,Valérian Dormoy,Valerie Odero-Marah,Venkata S. Sabbisetti,Véronique Maguer-Satta,W. Kimryn Rathmell,Wilhelm Engström,William K. Decker,William H. Bisson,Yon Rojanasakul,Yunus A. Luqmani,Zhenbang Chen,Zhiwei Hu +180 more
TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.
Journal ArticleDOI
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
R. Brooks Robey,R. Brooks Robey,Judith Weisz,Nancy B. Kuemmerle,Anna C. Salzberg,Arthur Berg,Dustin G. Brown,Laura L. Kubik,Roberta Palorini,Fahd Al-Mulla,Rabeah Al-Temaimi,Annamaria Colacci,Chiara Mondello,Jayadev Raju,Jordan Woodrick,A. Ivana Scovassi,Neetu Singh,Monica Vaccari,Rabindra Roy,Stefano Forte,Lorenzo Memeo,Hosni Salem,Amedeo Amedei,Roslida Abd Hamid,Graeme Williams,Leroy Lowe,Joel N. Meyer,Francis Martin,William H. Bisson,Ferdinando Chiaradonna,Elizabeth P. Ryan +30 more
TL;DR: A literature review to identify environmentally relevant exposures unambiguously linked to both cancer development and dysregulated metabolism suggests major gaps in understanding of exposure-associated carcinogenesis and metabolic reprogramming.
Journal ArticleDOI
MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1
TL;DR: The first microRNA is discovered that directly regulates TTF-1 by interacting with its 3’-untranslated region and this discovery connects the lung transcriptional program to the microRNA network.
Journal ArticleDOI
Regulation of UDP-glucuronosyltransferase 1A1 expression and activity by microRNA 491-3p.
Douglas F. Dluzen,Dongxiao Sun,Anna C. Salzberg,Nate Jones,Ryan T. Bushey,Gavin P. Robertson,Philip Lazarus +6 more
TL;DR: Results suggest that miR-491-3p is an important factor in regulating the expression of UGT1A enzymes in vivo, and in silico analysis identified miRNA 491-3P as a potential regulator of the U GT1A gene family via binding to the shared UGT 1A 3′-untranslated region common to all UGT2A enzymes.