Hyun Ho Park

TL;DR: This chapter reviews the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.

TL;DR: The crystal structure of the PIDD DD and RAIDD DD complex, which forms the core of the caspase-2-activating complex PIDDosome, is reported, which provides eight unique asymmetric interfaces, which can be classified into three types.

TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.

TL;DR: Although NALP3 PYD has the canonical six-helical bundle structural fold similar to other PYDs, the high resolution structure reveals the possible biologically important homodimeric interface and the dynamic properties of the fold and compares with other PYD structures shows both similarities and differences that may be functionally relevant.

TL;DR: The greener-synthesized silver nanoparticles can be used as an antifungal agent against wood-degrading fungal pathogens.