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B. Brett Finlay
Researcher at University of British Columbia
Publications - 609
Citations - 69318
B. Brett Finlay is an academic researcher from University of British Columbia. The author has contributed to research in topics: Virulence & Effector. The author has an hindex of 135, co-authored 588 publications receiving 61894 citations. Previous affiliations of B. Brett Finlay include Vaccine and Infectious Disease Organization & Canadian Institute for Advanced Research.
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Journal ArticleDOI
Gut Microbiota in Health and Disease
TL;DR: The advances in modeling and analysis of gut microbiota will further the authors' knowledge of their role in health and disease, allowing customization of existing and future therapeutic and prophylactic modalities.
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Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine
Ivaylo I. Ivanov,Rosa de Llanos Frutos,Nicolas Manel,Keiji Yoshinaga,Daniel B. Rifkin,R. Balfour Sartor,B. Brett Finlay,Dan R. Littman +7 more
TL;DR: It is reported that Th17 cell differentiation in the lamina propria of the small intestine requires specific commensal microbiota and is inhibited by treating mice with selective antibiotics, suggesting composition of intestinal microbiota regulates the Th17:Treg balance in the LP and may thus influence intestinal immunity, tolerance, and susceptibility to inflammatory bowel diseases.
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Common themes in microbial pathogenicity revisited.
B. Brett Finlay,Stanley Falkow +1 more
TL;DR: Comprehension of common themes in microbial pathogenicity is critical to the understanding and study of bacterial virulence mechanisms and to the development of new "anti-virulence" agents, which are so desperately needed to replace antibiotics.
Journal ArticleDOI
Early infancy microbial and metabolic alterations affect risk of childhood asthma
Marie-Claire Arrieta,Leah T. Stiemsma,Pedro A. Dimitriu,Lisa Thorson,Shannon L. Russell,Sophie Yurist-Doutsch,Boris Kuzeljevic,Matthew J. Gold,Heidi Britton,Diana L. Lefebvre,Padmaja Subbarao,Piush J. Mandhane,Allan B. Becker,Kelly M. McNagny,Malcolm R. Sears,Tobias R. Kollmann,William W. Mohn,Stuart E. Turvey,B. Brett Finlay +18 more
TL;DR: It is reported in a longitudinal human study that infants at risk of asthma have transient gut microbial dysbiosis during the first 100 days of life, and certain bacterial genera were decreased in these children, suggesting a potential causative role of the loss of these microbes.
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Enteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells
Brendan Kenny,Rebekah DeVinney,Markus Stein,Dieter J. Reinscheid,Elizabeth A. Frey,B. Brett Finlay +5 more
TL;DR: It is demonstrated that Hp90 is actually a bacterial protein (Tir), to which this bacterial pathogen inserts its own receptor into mammalian cell surfaces, to which it then adheres to trigger additional host signaling events and actin nucleation.