Catherine Hambly

TL;DR: A consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models is presented, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof.

TL;DR: This review provides some examples of the animal work that has been performed, and focuses on the variation in approaches that have been taken and their potential, rather than aiming to be a comprehensive summary.

TL;DR: Gavage of the bacterial metabolite butyrate increased the thermogenic capacity of ABX-treated mice, reversing the deficit and indicating that gut microbiota contributes to upregulated thermogenesis in the cold environment and that this may be partially mediated viabutyrate.

TL;DR: In this article, the authors analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years and found that fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults.

TL;DR: Morphological, behavioral, physiological, and genetic adaptations allow pandas to survive on their low-energy bamboo diet, and a unique mutation in the DUOX2 gene might explain these low thyroid hormone levels.