C
Cristina Bonorino
Researcher at Universidade Federal de Ciências da Saúde de Porto Alegre
Publications - 89
Citations - 2339
Cristina Bonorino is an academic researcher from Universidade Federal de Ciências da Saúde de Porto Alegre. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 24, co-authored 85 publications receiving 1828 citations. Previous affiliations of Cristina Bonorino include Universidade Federal do Rio Grande do Sul & University of Health Sciences Antigua.
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Journal ArticleDOI
The anti-inflammatory mechanisms of Hsp70
Thiago J. Borges,Lotte Wieten,Martijn J. C. van Herwijnen,Femke Broere,Ruurd van der Zee,Cristina Bonorino,Willem van Eden +6 more
TL;DR: The evidence on anti-inflammatory effects of Hsp70 is presented and the need for experiments that will be crucial for the further exploration of the immunosuppressive potential of this protein is discussed.
Journal ArticleDOI
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.
Yunlong Zhao,Calvin K. Lee,Chia-Hao Lin,Rodrigo Benedetti Gassen,Xiaozheng Xu,Zhe Huang,Changchun Xiao,Cristina Bonorino,Cristina Bonorino,Li-Fan Lu,Jack D. Bui,Enfu Hui +11 more
TL;DR: PD-L1 exerts an immunostimulatory effect by repressing the CTLA-4 axis; this has implications to the synergy of anti-PD- L1 and anti-CTLA- 4 combination therapy.
Journal ArticleDOI
Defining the critical hurdles in cancer immunotherapy
Bernard A. Fox,Bernard A. Fox,Dolores J. Schendel,Lisa H. Butterfield,Steinar Aamdal,James P. Allison,James P. Allison,Paolo A. Ascierto,Michael B. Atkins,Jirina Bartunkova,Lothar Bergmann,Neil L. Berinstein,Cristina Bonorino,Ernest C. Borden,Jonathan L. Bramson,Cedrik M. Britten,Xuetao Cao,Xuetao Cao,William E. Carson,Alfred E. Chang,Dainius Characiejus,A. Raja Choudhury,George Coukos,Tanja D. de Gruijl,Robert O. Dillman,Harry Dolstra,Glenn Dranoff,Lindy G. Durrant,James H. Finke,Jérôme Galon,Jared Gollob,Cécile Gouttefangeas,Fabio Grizzi,Michele Guida,Leif Håkansson,Kristen Hege,Kristen Hege,Ronald B. Herberman,F. Stephen Hodi,Axel Hoos,Christoph Huber,Patrick Hwu,Kohzoh Imai,Elizabeth M. Jaffee,Sylvia Janetzki,Carl H. June,Pawel Kalinski,Howard L. Kaufman,Koji Kawakami,Yutaka Kawakami,Ulrich Keilholtz,Samir N. Khleif,Rolf Kiessling,Beatrix Kotlan,Guido Kroemer,Réjean Lapointe,Hyam I. Levitsky,Michael T. Lotze,Cristina Maccalli,Michele Maio,Jens Peter Marschner,Michael J. Mastrangelo,Giuseppe Masucci,Ignacio Melero,C. J. M. Melief,William J. Murphy,Brad H. Nelson,Andrea Nicolini,Michael I. Nishimura,Kunle Odunsi,Pamela S. Ohashi,Jill O'Donnell-Tormey,Lloyd J. Old,Christian H. Ottensmeier,Michael Papamichail,Giorgio Parmiani,Graham Pawelec,Enrico Proietti,Shukui Qin,Robert C. Rees,Antoni Ribas,Ruggero Ridolfi,Gerd Ritter,Gerd Ritter,Licia Rivoltini,Pedro Romero,Mohamed L. Salem,Rik J. Scheper,Barbara Seliger,Padmanee Sharma,Hiroshi Shiku,Harpreet Singh-Jasuja,Wenru Song,Per thor Straten,Hideaki Tahara,Zhigang Tian,Zhigang Tian,Sjoerd H. van der Burg,Paul von Hoegen,Ena Wang,Marij J. P. Welters,Hauke Winter,Tara Withington,Jedd D. Wolchok,Weihua Xiao,Laurence Zitvogel,Heinz Zwierzina,Francesco M. Marincola,Thomas F. Gajewski,Jon M. Wigginton,Mary L. Disis +110 more
TL;DR: The critical hurdles identified by representatives of the collaborating organizations, now organized as the World Immunotherapy Council, are presented and discussed in this report.
Journal ArticleDOI
Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance.
Julia C. Fontoura,Christian Viezzer,Fabiana G. dos Santos,Rosane Angélica Ligabue,Ricardo Weinlich,Renato David Puga,Dyeison Antonow,Patrícia Severino,Cristina Bonorino,Cristina Bonorino +9 more
TL;DR: Two novel fully synthetic scaffolds produced using the polymer polyhydroxybutyrate (PHB) are introduced: a Solvent-Casting Particle-Leaching (SCPL) membrane; and an electrospun membrane, to be used for 3D cultures of B16 F10 murine melanoma cells and 4T1 murine breast cancer cells, which show similarities among all 3D platforms.
Journal ArticleDOI
Respiratory syncytial virus fusion protein promotes TLR-4-dependent neutrophil extracellular trap formation by human neutrophils.
Giselle A. Funchal,Natália Jaeger,Rafael S. Czepielewski,Mileni S. Machado,Stéfanie Primon Muraro,Renato T. Stein,Cristina Bonorino,Bárbara N. Porto +7 more
TL;DR: It is proposed that targeting the binding of TLR-4 by F protein could potentially lead to novel therapeutic approaches to help control RSV-induced inflammatory consequences and pathology of viral bronchiolitis.