David W. Johnson

TL;DR: Using primary cultures of human proximal tubule cells and renal cortical fibroblasts as an in vitro model of the tubulointerstitium, it is demonstrated that clinically relevant concentrations of CyA are directly toxic to cells and promote fibrogenesis by a combination of suppressed matrix metalloproteinase activity and augmented fibroblast collagen synthesis.

TL;DR: It is demonstrated herein that chemically designed nanolaminates, consisting of an intergrowth of chemically and structurally distinct components, comprise a class of materials in which this level of control can be achieved for one crystallographic direction.

TL;DR: Improved analytical sensitivity and specificity afforded by these derivatives may help to establish liquid chromatography tandem mass spectrometry (LC-MS/MS) with derivatization generated isotope-labelled standards a viable alternative to amino acids analysers.

TL;DR: Evidence is provided for common genetic susceptibility to AL amyloidosis and multiple myeloma, and Cyclin D1 is a more prominent driver in AL ameloidosis than in MM, but the links to aggregation of light chains need to be demonstrated.

TL;DR: In this paper, the authors describe the new components and techniques that have contributed most to improved data quality and reliability in the ten-year evolution of these systems and compare the design parameters of the systems.