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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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In Vitro and In Vivo Liposome-Mediated Gene Transfer Leads to Human MDR1 Expression in Mouse Bone Marrow Progenitor Cells
Ivan Aksentijevich,Ira Pastan,Yanto Lunardi-Iskandar,Robert C. Gallo,Michael M. Gottesman,Alain R. Thierry +5 more
TL;DR: Efficient expression of the human MDR1 gene in mouse BMC after transfection with a liposomal delivery system (DLS-liposomes) is demonstrated, demonstrating functional expression of a selectable gene in hematopoietic progenitor cells for up to 1 month.
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Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using single photon emission computed tomography-computed tomography (SPECT-CT) imaging.
Liza Lindenberg,Anish Thomas,Stephen Adler,Esther Mena,Karen A. Kurdziel,Julia D. Maltzman,Bruce A. Wallin,Kimberly Hoffman,Ira Pastan,Chang Hum Paik,Peter L. Choyke,Raffit Hassan +11 more
TL;DR: The results show that 111In-amatuximab was well tolerated with a favorable dosimetry profile and localizes to mesothelin expressing cancers with a higher uptake in mesothelioma than pancreatic cancer.
Journal Article
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
Zhengsheng Yao,Meili Zhang,Donald B. Axworthy,Karen J. Wong,Kayhan Garmestani,Luke Park,Chang W. Park,Robert W. Mallett,Louis J. Theodore,Eric K Yau,Thomas A. Waldmann,Martin W. Brechbiel,Chang H. Paik,Ira Pastan,Jorge A. Carrasquillo +14 more
TL;DR: Tumor pretargeting with B3-SA and radiolabeled DOTA-biotin has shown favorable, specific, and fast targeting that has resulted in good tumor responses and, thus, serves as a rationale for human studies with the B 3-SApretargeting approach.
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Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin.
TL;DR: It is found that uptake was saturable and that half-maximal uptake occurred at 130 nM R-alpha 2M, and that NRK cells can take up 10(6) molecules of R- alpha 2M per hour via receptor-mediated endocytosis.
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PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon.
Xiu Fen Liu,Pär Olsson,Curt D. Wolfgang,Tapan K. Bera,Paul H. Duray,Byungkook Lee,Ira Pastan +6 more
TL;DR: The database of human Expressed Sequence Tags (dbEST) is used to identify PRAC, a novel gene specifically expressed in human Prostate, prostate cancer, Rectum And distal Colon.