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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Transepithelial transport of vinblastine by kidney-derived cell lines. Application of a new kinetic model to estimate in situ Km of the pump.
TL;DR: The transepithelial transport of the chemotherapeutic drug, vinblastine, in epithelia formed by the kidney cell lines MDCK, LLC-PK1, and OK is studied and the transport pattern observed is that predicted to result from the function of the multidrug transporter in the apical plasma membrane.
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Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines.
K M Yamada,S S Yamada,Ira Pastan +2 more
TL;DR: It is indicated that a major decrease in this cell surface glycoprotein can occur in the establishment of a continuous cell line without resulting in cellular transformation.
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Barnase toxin: A new chimeric toxin composed of pseudomonas exotoxin A and barnase
TL;DR: It is concluded that the cytotoxic effect of the chimeric toxin was due to the ribonuclease activity of barnase molecules that had been translocated to the cytosol.
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Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.
TL;DR: A model of gene amplification in which small circular extrachromosomal DNA elements generated from contiguous chromosomal DNA regions multimerize to form cytologically detectable double minute chromosomes (DMs) is strongly supported.
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Identification of novel human CTL epitopes and their agonist epitopes of mesothelin.
Junko Yokokawa,Claudia Palena,Philip M. Arlen,Raffit Hassan,Mitchell Ho,Ira Pastan,Jeffrey Schlom,Kwong Y. Tsang +7 more
TL;DR: The identification of novel CTL agonist epitopes supports and extends observations that mesothelin is a potential target for immunotherapy of pancreatic and ovarian cancers, as well as mesotheliomas.