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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization
Frederick R. Maxfield,Joseph Schlessinger,Joseph Schlessinger,Yoram Shechter,Ira Pastan,Mark C. Willingham +5 more
TL;DR: All three polypeptides of insulin, epidermal growth factor and alpha2-macroglobulin are internalized within the same vesicles by a common pathway.
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A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.
Kazumichi Yoshida,Dai Watanabe,Hiroshi Ishikane,Masao Tachibana,Ira Pastan,Shigetada Nakanishi +5 more
TL;DR: Starburst cell ablation in the adult retina abolished not only directional selectivity of ganglion cell responses but also an optokinetic eye reflex derived by stimulus movement.
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Improving antibody affinity by mimicking somatic hypermutation in vitro.
Partha S. Chowdhury,Ira Pastan +1 more
TL;DR: A strategy to improve antibody affinity in vitro using phage display technology and should be generally applicable for the rapid isolation of higher-affinity mutants of Fvs, Fabs, and other recombinant antibodies from antibody phage libraries that are small in size.
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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
TL;DR: In this paper, a photoactive analog of prazosin was used to demonstrate the presence of two non-identical drug-interaction sites within P-glycoprotein (Pgp).
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α-Galactosidase A deficient mice: A model of Fabry disease
Toshio Ohshima,Gary J. Murray,William D. Swaim,Glenn Longenecker,Jane M. Quirk,Carol O. Cardarelli,Yoshikazu Sugimoto,Ira Pastan,Michael M. Gottesman,Roscoe O. Brady,Ashok B. Kulkarni +10 more
TL;DR: The similarity of the pathophysiological process in the mutant mice and in patients with Fabry disease is indicated, indicating the importance of an animal model for exploring therapeutic strategies for patients withFabry disease.