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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate
Tapan K. Bera,Sudipto Das,Hiroshi Maeda,Richard Beers,Curt D. Wolfgang,Vasantha Kumar,Yoonsoo Hahn,Byungkook Lee,Ira Pastan +8 more
TL;DR: Immunocytochemical analysis of cells transfected with NGEP cDNAs containing a Myc epitope tag at the carboxyl terminus shows that the protein encoded by the short transcript is localized in the cytoplasm, whereas the protein encode by the long transcript is present on the plasma membrane.
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Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector.
TL;DR: The ability to select for expression of GC with natural product drugs after introduction of the pHaMCG retroviral vector may be useful in gene therapy strategies for Gaucher disease.
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Renaturation of a single-chain immunotoxin facilitated by chaperones and protein disulfide isomerase.
TL;DR: Under optimum conditions, reactivation yields in the presence of PDI were about twice that obtained with nonenzymatic disulfide bond formation, and DnaK andPDI were additive when renaturation was performed in the absence of both proteins.
Journal ArticleDOI
Change in growth and morphology of fibroblasts by prostaglandins.
George S. Johnson,Ira Pastan +1 more
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The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia.
Robert J. Kreitman,Vijay K. Chaudhary,T. A. Waldmann,Mark C. Willingham,Desmond J. Fitzgerald,Ira Pastan +5 more
TL;DR: Results indicate that anti-Tac(Fv)-PE40 is a potent cytotoxin against adult T-cell leukemia cells in vitro and warrants clinical testing.