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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA
V. Enrico Avvedimento,Gabriel Vogeli,Yoshihiko Yamada,J.V. Maizel,Ira Pastan,Benoit de Crombrugghe +5 more
TL;DR: The nucleotide sequence of two short introns in the chick alpha 2-collagen (type I) gene as well as parts of the adjacent exons are determined and it is found that the 5' end of U1 RNA is complementary not only to the two ends of the intron but also to one end of the Intron and sequences inside this intron.
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A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity
Yang Feng,Xiaodong Xiao,Zhongyu Zhu,Emily Streaker,Mitchell Ho,Ira Pastan,Dimiter S. Dimitrov +6 more
TL;DR: The identification and characterization of a novel fully human monoclonal antibody, m912, which was isolated from a human Fab library by panning against recombinant mesothelin and has potential for cancer treatment and diagnosis.
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Selective Elimination of Human Regulatory T Lymphocytes In Vitro With the Recombinant Immunotoxin LMB-2
Peter Attia,Daniel J. Powell,Ajay V. Maker,Robert J. Kreitman,Ira Pastan,Steven A. Rosenberg +5 more
TL;DR: In vitro incubation of human PBMCs with LMB-2 reduced the levels of CD4+CD25+ and Foxp3-expressing cells without impairing the function of the remaining lymphocytes, making it an attractive candidate for reducing human Treg cells in vivo before the administration of cancer vaccine or cell transfer immunotherapy approaches.
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Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas.
TL;DR: Since KI reacts with a majority of cervical and esophageal carcinomas but has no detectable reactivity in normal epithelia of the cervix uteri and Esophagus, MAb KI could be of value as a reagent to help distinguish between normal and neoplastic cells on sections as well as in cytological samples.
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Intracellular localization of actin in cultured fibroblasts by electron microscopic immunocytochemistry.
TL;DR: The results suggest that actin has an important role in cell motility and adhesion, and in the endocytosis of pinosomes, but that actIn may not be involved in intracellular processes such as saltatory motion of intrace cellular organelles.