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Ira Pastan

Researcher at Laboratory of Molecular Biology

Publications -  1304
Citations -  113191

Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.

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Journal ArticleDOI

Certain functions of isolated thyroid cells.

Ira Pastan
- 01 Jun 1961 - 
TL;DR: A technique for dispersing thyroid tissue into single cells is described, in which Thyroglobulin, serum albumin and tyrosine are iodinated when added to the incubation medium, although the iodinated material formed by unfortified cells does not appear to be thyrogLobulin.
Journal ArticleDOI

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

Vidyalakshmi Chandramohan, +12 more
- 29 May 2019 - 
TL;DR: D2C7-IT-induced immune response could be effectively augmented in combination with αCTLA-4/ αPD-1/αPD-L1 therapies in murine models of glioma, and combination therapy-induced systemic antitumor response was effective against both dmEGFRvIII-positive and dm EGFRv III-negative CT-2A tumors.
Book ChapterDOI

Growth Hormone and Prolactin

Paul A. Kelly, +3 more
Journal Article

Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.

Robert J. Kreitman, +6 more
- 15 Oct 1992 - 
TL;DR: Mik-beta 1(Fv)-PE40 may be a useful reagent to study cells that express IL-2R, and it deserves further study as a possible treatment for cancers in which the malignant cells express high numbers of p75 subunit.
Journal ArticleDOI

Properties and purification of a glucose-regulated protein from chick embryo fibroblasts.

Robert P.C. Shiu, +1 more
- 25 Jan 1979 - 
TL;DR: Immunofluorescence studies using affinity purified antibodies to GRP-78 revealed that this protein was not exposed on the cell surface but was localized in a granular vesicular network inside the cell that resembles the distribution of endoplasmic reticulum.