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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface.
TL;DR: The possibility that amines and ammonia would block the clustering of α2M and EGF is examined, and it is reported here that these agents are effective in blocking clustering and internalisation.
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Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL.
TL;DR: It is suggested that the altered carboxyl terminus of Pseudomonas exotoxin may enable the toxin to interact more efficiently with a cellular component involved in translocation of the toxins to the cytosol.
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Ablation of Cerebellar Golgi Cells Disrupts Synaptic Integration Involving GABA Inhibition and NMDA Receptor Activation in Motor Coordination
Dai Watanabe,Hitoshi Inokawa,Kouichi Hashimoto,Norimitsu Suzuki,Masanobu Kano,Ryuichi Shigemoto,Tomoo Hirano,Keisuke Toyama,Satoshi Kaneko,Mineto Yokoi,Koki Moriyoshi,Misao Suzuki,Kazuto Kobayashi,Toshiharu Nagatsu,Robert J. Kreitman,Ira Pastan,Shigetada Nakanishi +16 more
TL;DR: Results demonstrate that synaptic integration involving both GABA inhibition and NMDA receptor activation is essential for compound motor coordination and this integration can adapt after Golgi cell elimination so as not to evoke overexcitation by the reduction of NMDA receptors.
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Purification of and Properties of the Cyclic Adenosine 3',5'-Monophosphate Receptor Protein which Mediates Cyclic Adenosine 3',5'-Monophosphate-dependent Gene Transcription in Escherichia coli
TL;DR: The ability of CRP to promote selected transcription is lost upon elution of the protein from phosphocellulose but activity is usually regained within 20 to 48 hours, and the preparation appears to be homogeneous as determined by sedimentation equilibrium studies, isoelectric focusing, and amino-terminal amino acid sequence analysis.
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Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments.
TL;DR: The biochemical features of dsFvs in comparison with scFvs, the effect of disulfide stabilization on Fv binding and activity, and various applications of dSFvs and ds Fv-immunotoxins for tumor imaging and the treatment of solid tumors in animal models are discussed.