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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
Ding-Wu Shen,Carol O. Cardarelli,Joonsung Hwang,M M Cornwell,Nancy D. Richert,Shunsuke Ishii,Ira Pastan,Michael M. Gottesman +7 more
TL;DR: It is suggested that only a limited number of protein changes occur in multidrug-resistant cell lines, which are associated with a loss of translatable mRNA for these proteins.
Journal Article
Reduced Drug Accumulation in Multiply Drug-resistant Human KB Carcinoma Cell Lines
TL;DR: The results suggest that, in this human epithelial cell, the development of resistance to multiple drugs is complex, with changes in drug uptake, accumulation, and efflux.
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Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene.
Thierry Velu,Laura Beguinot,William C. Vass,Mark C. Willingham,Glenn Merlino,Ira Pastan,Douglas R. Lowy +6 more
TL;DR: The EGFR retrovirus, which had a titer on NIH 3T3 cells that was greater than 10(7) focus-forming units per milliliter, can efficiently transfer and express this gene, and increased numbers of EGF receptors can contribute to the transformed phenotype.
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The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein
Kazumitsu Ueda,Marilyn M. Cornwell,Michael M. Gottesman,Ira Pastan,Igor B. Roninson,Victor Ling,John R. Riordan +6 more
TL;DR: It is shown that human KB carcinoma cells which express the mdr1 gene also express P-glycoprotein, and that cDNAs encoding P- glycoprotein cross-hybridize with m dr1 cDN as, Thus, the mDr1 gene codes for P- Glycoprotein.
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Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth.
TL;DR: There is an inverse correlation between growth rate and cyclic AMP levels and contact inhibition of growth in cultured fibroblasts when many lines are compared during logarithmic growth.