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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models
Yasmin Leshem,Ira Pastan +1 more
TL;DR: In this paper, the authors discuss patterns of clinical responses suggesting that PE immunotoxins can provoke anti-tumor immunity, and review murine models that further support this ability.
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Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
Chien-Tsun Kuan,Ira Pastan +1 more
TL;DR: It is suggested that reduction of the disulfide bond connecting the dsFv heterodimer occurs before the immunotoxin reaches the ER, where translocation to the cytosol appears to occur.
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Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes.
TL;DR: These antibodies should be useful as probes for monitoring the activation and processing of PE that occur during endocytosis and in determining the location of epitopes that are important for toxin activity.
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The T Cell Receptor γ Chain Alternate Reading Frame Protein (TARP), a Prostate-specific Protein Localized in Mitochondria *
TL;DR: It is demonstrated that Tarp is the first prostate-specific protein localizing in mitochondria and indicate that TARP, an androgen-regulated protein, may act on mitochondria to carry out its biological functions.
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A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.
Wenhai Liu,Masanori Onda,Changhoon Kim,Changhoon Kim,Laiman Xiang,John E. Weldon,Byungkook Lee,Ira Pastan +7 more
TL;DR: It is demonstrated that it is possible to design mutations in a protein molecule that will increase the stability of the protein and thereby reduce its immunogenicity.