I
Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation.
Ronit Mazor,Ira Pastan +1 more
TL;DR: The immunogenicity of the original and de-immunized PE immunotoxins in mice and patients is reviewed, the development of anti-drug antibodies (ADAs), their impact on drug availability and their effect on clinical efficacy are reviewed.
Journal ArticleDOI
Activation of Adenylate Cyclase in Cultured Fibroblasts by Trypsin
TL;DR: The present results suggest that this change in adenylate cyclase activity in membranes of cultured normal rat kidney (NRK) fibroblasts is not due to an increase in the amount ofAdenylates cyclase in the cell membrane but rather to a change in membrane components that regulate its activity.
Journal ArticleDOI
Adenovirus-dependent increase in cell membrane permeability.
TL;DR: The Ad2-dependent release of choline was found to be dependent on Ad2 concentration, with maximum release at 10 micrograms/ml of Ad2 on the length of the incubation with Ad2, and on the medium pH with maximum activity at pH 6.0 to 6.5.
Journal ArticleDOI
Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy
Hui Wei,Laiman Xiang,Alan S. Wayne,Oleg Chertov,David J. FitzGerald,Tapan K. Bera,Ira Pastan +6 more
TL;DR: The data show that immunotoxin resistance is associated with reversible CpG island methylation and silencing of DPH4 gene transcription, which prevents diphthamide biosynthesis and renders EF2 refractory to HA22.
Journal ArticleDOI
Thyroid hormone down-regulates p55, a thyroid hormone-binding protein that is homologous to protein disulfide isomerase and the beta-subunit of prolyl-4-hydroxylase.
TL;DR: Results indicated that down-regulation of p55 by T3 occurs at the post-translational level, and T3 may mediate its effects on the synthesis, secretion, and/or transport of proteins via p55.