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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Insertion of constant region domains of human IgG, into CD4-PE40 increases its plasma half-life
Janendra K. Batra,Sanjeevaiah Kasturi,Maria Gallo,Richard L. Voorman,Stephen M. Maio,Vijay K. Chaudhary,Ira Pastan +6 more
TL;DR: It is proposed that insertion of the CH2 domain into CD4-PE40 covers up the protease sensitive sites in the molecule, thereby making the molecule less susceptible to degradation.
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Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy
Vidyalakshmi Chandramohan,Xuhui Bao,Stephen T. Keir,Charles N. Pegram,Scott E. Szafranski,Hailan Piao,Carol J. Wikstrand,Roger E. McLendon,Chien-Tsun Kuan,Ira Pastan,Darell D. Bigner +10 more
TL;DR: In preclinical studies, the D2C7-(scdsFv)-PE38KDEL immunotoxin exhibited significant potential for treating brain tumors expressing EGFRwt, EGFRvIII, or both.
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Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cells.
TL;DR: The observation that the majority of the receptor was found in the endoplasmic reticulum and structures similar to GERL raises the possibility that the PM receptor plays an important role in compartmentalization of lysosomal enzymes in the GERL system.
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CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses.
Edward A. Berger,Kathleen A. Clouse,Vijay K. Chaudhary,Sekhar Chakrabarti,David J. FitzGerald,Ira Pastan,Bernard Moss +6 more
TL;DR: Using recombinant vaccinia viruses as expression vectors, the hybrid toxin was found to be active against cells expressing the envelope glycoproteins of divergent isolates of HIV-1, as well as HIV-2 and simian immunodeficiency virus, providing further support for the therapeutic potential of CD4(178)-PE40 in the treatment of infected individuals.
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Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas
Chien-Tsun Kuan,Kenji Wakiya,Stephen T. Keir,Jianjun Li,James E. Herndon,Ira Pastan,Darell D. Bigner +6 more
TL;DR: Glycoprotein NMB‐specific scFv antibodies and immunotoxins hold promise as reagents in targeted therapy for HGGs and other GPNMB‐expressing malignancies.