Ira Pastan

TL;DR: Alpha 2-macroglobulin is internalized into cultured fibroblasts by receptor-mediated endocytosis and interacts with the Golgi-endoplasmic reticulum-lysosome system in the cell to deliver the ligand to newly formed lysosomes within 30--60 min.

TL;DR: A safety-modified vector, pSXLC/pHa, was constructed to coexpress drug-selectable markers with a second gene of interest as a part of a bicistronic mRNA in a retroviral vector using an internal ribosome entry site (IRES) from encephalomyocarditis virus.

TL;DR: It is demonstrated that the number of chelate conjugation and the injected dose are two important parameters to achieve high tumor and low non-target organ uptake of (111)In-labeled MORAb-009 and suggested that the injected doses of mAb could be individualized based on the tumor size or the blood level of shed antigen in a patient to achieve the ideal tumor-to-organ radioactivity ratios.

TL;DR: This paper summarizes the experimental evidence which led to the demonstration of the role of cyclic AMP and its receptor protein (CRP) in the activation of gene transcription in bacteria and examines its function in the control of the galactose operon of Escherichia coli.

TL;DR: The smaller size of the Fab immunotoxins compared to B3Lys-PE38 and the increased T1/2 value compared toB3(scFv)- PE38 and B3(dsFV)-PE38 make these recombinant immunotoxinins alternative therapeutic agents to treat Ley antigen positive cancers.