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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.
TL;DR: The results suggest a complex pattern of regulation of mdr RNA levels, depending on animal species and cell type, and possible coordinate regulation with topoisomerase II RNA levels.
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A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses
Daniel H. Sterman,Adri Recio,Richard G. Carroll,Colin T. Gillespie,Andrew R. Haas,Anil Vachani,Veena Kapoor,Jing Sun,Richard L. Hodinka,Jennifer L. Brown,Michael J. Corbley,Michael Parr,Mitchell Ho,Ira Pastan,Michael Machuzak,William F. Benedict,Xin Qiao Zhang,Elaina M. Lord,Leslie A. Litzky,Daniel F. Heitjan,Carl H. June,Larry R. Kaiser,Robert H. Vonderheide,Steven M. Albelda +23 more
TL;DR: Intrapleural instillation of Ad.IFN-β is a potentially useful approach for the generation of antitumor immune responses in MPM and MPE patients and should be investigated further for overall clinical efficacy.
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Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma.
TL;DR: This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma.
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Cyclic 3′5′-AMP: Stimulation of β-galactosidase and tryptophanase induction in E. Coli
Robert L. Perlman,Ira Pastan +1 more
TL;DR: It is reported that cyclic 3′,5′-AMP increases the differential rate of synthesis of two inducible enzymes, β-galactosidase and tryptophanase, when the synthesis of these enzymes is repressed by glucose and pyruvate respectively.
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Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation.
TL;DR: Calcium is thought to be required for the binding of adrenal corticotrophic hormone (ACTH) to its cellular receptor and inhibit the activation of adenyl cyclase by ACTH in subcellular particles from adipose and adrenal tissue.