I
Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Cardiac allograft survival in mice treated with IL-2-PE40
Haya Lorberboum-Galski,Leslie V. Barrett,Robert L. Kirkman,Masato Ogata,Mark C. Willingham,David J. FitzGerald,Ira Pastan +6 more
TL;DR: It is demonstrated that intraperitoneally administered IL-2-PE40 specifically and significantly prolongs the survival of vascularized heart allografts in mice and offers an alternative approach to the treatment of autoimmune diseases and transplant rejection in humans.
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Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence
Mark E. Sobel,Tadashi Yamamoto,S L Adams,R DiLauro,Vittorio Enrico Avvedimento,B de Crombrugghe,Ira Pastan +6 more
TL;DR: A recombinant plasmid containing chick pro-alpha2 collagen gene sequences has been constructed and cloned in Escherichia coli and was shown to contain pro- alpha2 collagen DNA by its specific hybridization to chickPro-alpha1 collagen mRNA, as assayed in an in vitro translation system.
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Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver.
TL;DR: The results suggest that a transcriptional and/or a posttranscriptional regulatory mechanism exists in regenerating rat liver with respect to EGF receptor gene expression.
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Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs.
Edward A. Berger,Ira Pastan +1 more
TL;DR: This work was supported in part by the Intramural Program of the NIH (National Institute of Allergy and Infectious Diseases; National Cancer Institute), including the NIH Intramurals AIDS Targeted Antiviral Program.
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Stimulation of membranous guanylate cyclase by concentrations of calcium that are in the physiological range
D. Wallach,Ira Pastan +1 more
TL;DR: It is suggested that the activity of guanylate cyclase in vitro with Mg 2+ represents its behavior in vivo and that Ca 2+ regulates cyclic GMP in cells by directly stimulating guany Late cyclase activity.