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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin
TL;DR: Dansylcadaverine is 20-fold more potent than amantadine in blocking virus and alpha 2-macroglobulin uptake, and one cellular target for both of these amine-containing compounds appears to be the clustering of membrane-bound ligands or particles in clathrin-coated pits.
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Responses in refractory hairy cell leukemia to a recombinant immunotoxin.
Robert J. Kreitman,Wyndham H. Wilson,David Robbins,Inger Margulies,Maryalice Stetler-Stevenson,T. A. Waldmann,Ira Pastan +6 more
TL;DR: Results represent a proof of principal that targeted therapy with recombinant Fv-containing proteins can be clinically useful and LMB-2 may be an effective new therapy for patients with chemotherapy-resistant CD25(+) HCL.
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Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.
Ding-Wu Shen,Antonio Tito Fojo,Igor B. Roninson,Janice E. Chin,R Soffir,Ira Pastan,Michael M. Gottesman +6 more
TL;DR: Amplification and expression of the human mdr1 sequences and amplification of cotransferred human Alu sequences in the mouse cells correlated with the degree of multidrug resistance, suggesting that the m dr1 gene is likely to be responsible for multidrog resistance in cultured cells.
Journal Article
Improved Cytotoxic Activity toward Cell Lines and Fresh Leukemia Cells of a Mutant Anti-CD22 Immunotoxin Obtained by Antibody Phage Display
TL;DR: The aim of the present study was to improve the activity of RFB4 (Fv)-PE38 to more effectively treat patients with leukemias and lymphomas by using the techniques of phage display and hot spot mutagenesis.
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Binding of hormone to tissue: the first step in polypeptide hormone action.
TL;DR: The persistent hormone effect was due to the continued presence of relatively intact hormone at a readily accessible tissue site, and Neutralization indicates that a solution of hormone and antibody, allowed to mix for 30 min, failed to stimulate glucose1-C14 oxidation in thyroid or glucose-1- C14 incorporation into rat diaphragms.