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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin Termed PE-38 (TP-38) for the Treatment of Malignant Brain Tumors
John Sampson,Gamal Akabani,Gary E. Archer,Darell D. Bigner,Mitchel S. Berger,Allan H. Friedman,Henry S. Friedman,James E. Herndon,Sandeep Kunwar,Steve Marcus,Roger E. McLendon,Alison Paolino,Kara Penne,James M. Provenzale,Jennifer A. Quinn,David A. Reardon,Jeremy N. Rich,Timothy T. Stenzel,Sandra Tourt-Uhlig,Carol J. Wikstrand,Terence Z. Wong,Roger L. Williams,Fan Yuan,Michael R. Zalutsky,Ira Pastan +24 more
TL;DR: The primary objective of this study was to define the MTD and dose limiting toxicity of TP-38 delivered by convection-enhanced delivery in patients with recurrent malignant brain tumors and one patient developed Grade IV fatigue at the 100ng/mL dose.
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Epidermal growth factor regulates the expression of its own receptor.
TL;DR: Results of nuclear runoff-transcription experiments suggest that the stimulatory effects of EGF and cycloheximide are most likely due to a posttranscriptional control mechanism.
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Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State †
Murali Ramachandra,Suresh V. Ambudkar,David Chen,Christine A. Hrycyna,Saibal Dey,Michael M. Gottesman,Ira Pastan +6 more
TL;DR: Human P-glycoprotein, a plasma membrane protein that confers multidrug resistance, functions as an ATP-dependent drug efflux pump and results in a conformation with reduced affinity for substrates that supports a model for drug transport in which an ATP hydrolysis-induced conformational change leads to drug release toward the extracellular medium.
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Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.
TL;DR: It is demonstrated that membrane vesicles from multiply drug-resistant cells bind increased amounts of vinblastine, which is known to reverse the multidrug-resistance phenotype.
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Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol.
TL;DR: The 37-kDa fragment appears to be essential for toxicity since mutant PE molecules that do not produce this fragment, or cannot deliver it to the cytosol, fail to kill cells.