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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Journal ArticleDOI
Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia
Robert J. Kreitman,Wyndham H. Wilson,Karen Bergeron,Miranda Raggio,Maryalice Stetler-Stevenson,David J. FitzGerald,Ira Pastan +6 more
TL;DR: BL22 can induce complete remissions in patients with hairy-cell leukemia that is resistant to treatment with purine analogues, including cladribine.
Journal ArticleDOI
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
Waleed Haso,Daniel W. Lee,Nirali N. Shah,Maryalice Stetler-Stevenson,Constance M. Yuan,Ira Pastan,Dimiter S. Dimitrov,Richard A. Morgan,David J. FitzGerald,David M. Barrett,Alan S. Wayne,Alan S. Wayne,Crystal L. Mackall,Rimas J. Orentas +13 more
TL;DR: It is concluded that second-generation m971 mAb-derived anti-CD22 CARs are promising novel therapeutics that should be tested in BCP-ALL.
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Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.
Peter J.A. Davies,Dana R. Davies,Alexander Levitzki,Alexander Levitzki,Frederick R. Maxfield,Pierre Milhaud,Mark C. Willingham,Ira Pastan +7 more
TL;DR: The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.
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A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin
Vijay K. Chaudhary,Cary L. Queen,Richard P. Junghans,Thomas A. Waldmann,Desmond J. Fitzgerald,Ira Pastan +5 more
TL;DR: Anti-Tac(Fv)–PE40 was very cytotoxic to two interleukin-2 receptor-bearing human cell lines but was not cytotoxicity to receptor-negative cells, suggesting that the construction and expression of this single chain antibody toxin fusion protein in E coli is likely to be influenced by its carrier status.
Journal ArticleDOI
Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1.
Brian P. Sorrentino,Stephen J. Brandt,David M. Bodine,Michael M. Gottesman,Ira Pastan,Amanda P. Cline,Arthur W. Nienhuis +6 more
TL;DR: This demonstration of positive selection establishes the ability to amplify clones of transduced hematopoietic cells in vivo and suggests possible applications in human therapy.