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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Journal ArticleDOI
N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells.
George S. Johnson,Ira Pastan +1 more
TL;DR: It is found that during treatment with dibutyryl cyclic AMP, melanoma cells spread out, appear larger and produce considerably more pigment than untreated cells.
Book ChapterDOI
The Pathway of Endocytosis
Ira Pastan,Mark C. Willingham +1 more
TL;DR: A wide variety of molecules have been observed to enter cells by receptor-mediated endocytosis: hormones, growth factors, transport proteins that carry cholesterol or iron, proteins modified for degradation, toxins and viruses.
Journal ArticleDOI
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus.
TL;DR: Various drugs and reversing agents compete with the [3H]azidopine binding reaction when added in excess, indicating that the recombinant human multidrug transporter expressed in insect cells is functionally similar to its authentic counterpart.
Journal ArticleDOI
Expression of the multidrug resistance gene in myeloid leukemias.
Hiroshi Sato,Michael M. Gottesman,Lori J. Goldstein,Ira Pastan,Anne Marie W. Block,Avery A. Sandberg,Harvey D. Preisler +6 more
TL;DR: Estimation of RNA transcript levels in leukemia cells obtained from 15 adult acute nonlymphocytic leukemia cases and 15 cases of chronic myelogenous leukemia support the idea that expression of the MDR1 gene contributes to drug resistance in ANLL and may play a role in some instances in the drug-resistance of CML in blastic crisis.
Journal ArticleDOI
Evidence for participation of transglutaminase in receptor-mediated endocytosis
TL;DR: Evidence is reported that the enzyme transglutaminase participates in receptor-mediated endocytosis and is inhibited by a wide spectrum of compounds that inhibit transglUTaminases, including that from NRK cells.