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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Cyclic AMP-dependent phosphorylation of filamin in mammalian smooth muscle.
TL;DR: Phosphorylation of filamin is a high molecular weight actin-binding protein found in large quantities in smooth muscle and other non-muscle cells and is due to a soluble kinase stimulated only by Cyclic AMP and not by cyclic GMP or Ca2+.
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Recombinant Toxins Containing Human Granulocyte-Macrophage Colony-Stimulating Factor and Either Pseudomonas Exotoxin or Diphtheria Toxin Kill Gastrointestinal Cancer and Leukemia Cells
Robert J. Kreitman,Ira Pastan +1 more
TL;DR: The fact that PE is more effective than DT in killing GI but not leukemic tumor cells targeted by GM-CSF indicates a fundamental difference in the way PE or DT gains access to the cytosol in these cells.
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Permanent Genetic Tagging of Podocytes: Fate of Injured Podocytes in a Mouse Model of Glomerular Sclerosis
TL;DR: When podocytes are severely injured, proliferating parietal epithelial cells migrate onto the visceral site, thereby mimicking proliferating podocytes, and the fate of injured podocytes was pursued.
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Retroviral Mediated Transfer of the Human Multidrug Resistance Gene (MDR-1) into Hematopoietic Stem Cells During Autologous Transplantation after Intensive Chemotherapy for Metastatic Breast Cancer. National Institutes of Health, Bethesda, Maryland
Joyce O'Shaughnessy,Kenneth H. Cowan,Arthur W. Nienhuis,Kevin T. McDonagh,Brian P. Sorrentino,Cynthia E. Dunbar,Yawen Chiang,Wyndham H. Wilson,Barry R. Goldspiel,David R. Kohler,Michele Cottler-Fox,Susan F. Leitman,Michael M. Gottesman,Ira Pastan,Andrea Denicoff,Marianne Noone,Ronald E. Gress +16 more
TL;DR: Patients with metastatic breast cancer will receive 4-5 cycles of induction chemotherapy on one of the ongoing Medicine Branch protocols to study whether chemotherapy amplifies the proportion of hematopoietic cells containing the MDR-1 provirus.
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Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells.
TL;DR: A chimeric toxin targeted toward the EGF receptor can selectively kill rapidly proliferating SMCs, and competition studies using excess EGF indicated that the cytotoxic effects of TGFa-PE40 are specifically mediated by the E GF receptor.