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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Rapid and Specific Uptake of Anti-Tac Disulfide-stabilized Fv by Interleukin-2 Receptor-bearing Tumors
TL;DR: Because of its rapid uptake by IL2 receptor-bearing tumors, short serum half-life, and increased stability, radiolabeled anti-Tac(dsFv) may be useful for the imaging and therapy of neoplasias expressing the IL2 receptors.
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Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma
Neetu Kalra,Jingli Zhang,Anish Thomas,Liqiang Xi,Mitchell Cheung,Jacqueline Talarchek,Sandra Burkett,Maria Tsokos,Yuanbin Chen,Mark Raffeld,Markku Miettinen,Ira Pastan,Joseph R. Testa,Raffit Hassan +13 more
TL;DR: The mesothelioma patient derived tumor xenografts with mutational alterations that mimic those observed in patient tumors which are established can be used for preclinical development of novel drug regimens and for studying the functional aspects of BAP1 biology in mesotelioma.
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GTP-stimulated phosphorylation of P-glycoprotein in transporting vesicles from KB-V1 multidrug resistant cells.
TL;DR: The results suggest that the overall phosphorylation of Pgp in vitro is determined by several different protein kinases and phosphatases, at least one of which may be GTP-regulated.
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Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results.
Emily Mason-Osann,Emily Mason-Osann,Kevin Hollevoet,Kevin Hollevoet,Gerhard Niederfellner,Ira Pastan +5 more
TL;DR: Comparing amounts of RIT delivered in vivo and in vitro can explain tumor responses and should facilitate the development of more active immunotoxins and other antibody based agents.
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Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection
TL;DR: Results demonstrate that urine outflow obstruction protects the glomerulus from progressive sclerosis, and reveals that this protection occurs at a very early stage of the pathologic process, namely, damage of podocytes.