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Ira Pastan
Researcher at Laboratory of Molecular Biology
Publications - 1304
Citations - 113191
Ira Pastan is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Immunotoxin & Pseudomonas exotoxin. The author has an hindex of 160, co-authored 1286 publications receiving 110069 citations. Previous affiliations of Ira Pastan include Heidelberg University & National Institutes of Health.
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Epidermal growth factor receptor gene promoter. Deletion analysis and identification of nuclear protein binding sites.
TL;DR: DNase I footprinting showed that this transcription factor can bind to four sites in the EGF receptor gene promoter and therefore may play a role in its regulation and quantitatively agree with exonuclease III protection.
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Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells
TL;DR: The pathway for internalization of beta-galactosidase via the mannose 6-phosphate receptor is similar to the pathway established for other ligands such as low density lipoprotein and alpha 2-macroglobulin.
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A Mutation in a Rous Sarcoma Virus Gene That Controls Adenosine 3′,5′-Monophosphate Levels and Transformation
TL;DR: Chicken embryo fibroblasts infected with a temperature-sensitive mutant of Rous sarcoma virus (RSV-Ta) have normal morphology at 40.5° but after a transfer to 36° show the morphological characteristics of transformed cells, suggesting that an early event in transformation leads to a decreased level of cyclic AMP.
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Expression of the multidrug resistance, MDR1, gene in neuroblastomas.
Lori J. Goldstein,Antonio Tito Fojo,Kazumitsu Ueda,William M. Crist,Alexander A. Green,Garrett M. Brodeur,Ira Pastan,Michael M. Gottesman +7 more
TL;DR: Results show that high levels of MDR1 RNA are often associated with resistance to chemotherapy in neuroblastoma and suggest that they may contribute to this resistance.
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Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients
Masanori Onda,Satoshi Nagata,David J. FitzGerald,Richard Beers,Robert J. Fisher,James J. Vincent,Byungkook Lee,Michihiro Nakamura,Jaulang Hwang,Robert J. Kreitman,Raffit Hassan,Ira Pastan +11 more
TL;DR: The results indicate that a relatively small number of discrete immunogenic sites are associated with PE38, most of which can be eliminated by point mutations.