Ira Pastan

TL;DR: Investigation of the effects of several PE-based ITs on different human endothelial cell lines suggests that VLS in patients is due to capillary damage caused by prolonged exposure to high concentrations of LMB-1, and evidence that the cytotoxicity of B3-containing ITs isdue to specific B3 binding to endothelial cells can be blocked by excess free MAb B3 is found.

TL;DR: Kinetic analyses of vinblastine and daunomycin accumulation in both the wild-type and the mutant cell lines during ACTH-stimulated steroidogenesis show that in the mutant cells both drugs accumulated to higher levels than in Y1 cells, suggesting that the remaining mdr1b allele in the Mutant cells is relatively inactive as an exporter of steroids.

TL;DR: It is suggested that intraperitoneal injection of immunotoxins may have a role in the treatment of ovarian cancer.

TL;DR: In this article, a single-chain antibody specific for the EGFRvIII mutation was expressed with a modified form of the Pseudomonas exotoxin to form the immunotoxin MR1scFvPE38KDEL (MR-1).

TL;DR: Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes), which have now been purified more than 37-fold based on their content of newly internalized epidermal growth factor.