L
Lesley Hoyles
Researcher at Nottingham Trent University
Publications - 120
Citations - 8449
Lesley Hoyles is an academic researcher from Nottingham Trent University. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 28, co-authored 102 publications receiving 6232 citations. Previous affiliations of Lesley Hoyles include University of Reading & University of Westminster.
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Journal ArticleDOI
Prebiotic effects: metabolic and health benefits.
Marcel Roberfroid,Glenn R. Gibson,Lesley Hoyles,Anne L. McCartney,Robert A. Rastall,Ian Rowland,Danielle Wolvers,Bernhard Watzl,Hania Szajewska,Bernd Stahl,Francisco Guarner,Frédérique Respondek,Kevin Whelan,Véronique Coxam,Marie-Jeanne Davicco,Laurent Léotoing,Yohann Wittrant,Nathalie M. Delzenne,Patrice D. Cani,Audrey M. Neyrinck,Agnes Meheust +20 more
TL;DR: The present document has been written by a group of both academic and industry experts and aims to validate and expand the original idea of the prebiotic concept, defined as the selective stimulation of growth and/or activity of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits to the host.
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Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology
Maria Carlota Dao,Amandine Everard,Judith Aron-Wisnewsky,Nataliya Sokolovska,Edi Prifti,Eric O. Verger,Brandon D. Kayser,Florence Levenez,Julien Chilloux,Lesley Hoyles,Marc-Emmanuel Dumas,Salwa W. Rizkalla,Joël Doré,Patrice D. Cani,Karine Clément +14 more
TL;DR: A. muciniphila is associated with a healthier metabolic status and better clinical outcomes after CR in overweight/obese adults, and the interaction between gut microbiota ecology and A. muc iniphila warrants further investigation.
Journal Article
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity : relationship with gut microbiome richness and ecology [plus Supplementary data]
Maria Carlota Dao,Amandine Everard,Judith Aron-Wisnewsky,Nataliya Sokolovska,Edi Prifti,Eric O. Verger,Brandon D. Kayser,Florence Levenez,Julien Chilloux,Lesley Hoyles,Marc E. Dumas,Salwa W. Rizkalla,Joël Doré,Patrice D. Cani,Karine Clément,S. Le Mouhaër,Aurélie Cotillard,Sean Kennedy,Nicolas Pons,Mathieu Almeida,Benoit Quinquis,Nathalie Galleron,Jean-Michel Batto,Pierre Renault,Jean-Daniel Zucker,S. Dusko Ehrlich,Hervé M. Blottière,Marion Leclerc,Catherine Juste,T. De Wouters,Patricia Lepage +30 more
TL;DR: In this paper, the authors evaluated the association between faecal A. muciniphila abundance and microbial gene richness after calorie restriction (CR) in overweight and obese adults.
Journal ArticleDOI
Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women.
Lesley Hoyles,José Manuel Fernández-Real,Massimo Federici,Matteo Serino,Matteo Serino,James Abbott,Julie Charpentier,Julie Charpentier,Christophe Heymes,Christophe Heymes,Jèssica Latorre Luque,Elodie Anthony,Richard H. Barton,Julien Chilloux,Antonis Myridakis,Laura Martinez-Gili,José María Moreno-Navarrete,Fadila Benhamed,Vincent Azalbert,Vincent Azalbert,Vincent Blasco-Baque,Vincent Blasco-Baque,Josep Puig,Gemma Xifra,Wifredo Ricart,Christopher Tomlinson,Mark Woodbridge,Marina Cardellini,Francesca Davato,Iris Cardolini,Ottavia Porzio,Ottavia Porzio,Paolo Gentileschi,Frédéric Lopez,Frédéric Lopez,Fabienne Foufelle,Sarah Butcher,Elaine Holmes,Jeremy K. Nicholson,Catherine Postic,Rémy Burcelin,Rémy Burcelin,Marc-Emmanuel Dumas +42 more
TL;DR: It is demonstrated that fecal microbiota transplants and chronic treatment with phenylacetic acid, a microbial product of aromatic amino acids metabolism, successfully trigger steatosis and branched-chain amino acid metabolism.
Journal ArticleDOI
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
Saeed Shoaie,Pouyan Ghaffari,Petia Kovatcheva-Datchary,Adil Mardinoglu,Partho Sen,Estelle Pujos-Guillot,Tomas de Wouters,Catherine Juste,Salwa W. Rizkalla,Salwa W. Rizkalla,Julien Chilloux,Lesley Hoyles,Jeremy K. Nicholson,Joël Doré,Marc E. Dumas,Karine Clément,Karine Clément,Karine Clément,Fredrik Bäckhed,Fredrik Bäckhed,Jens Nielsen +20 more
TL;DR: The CASINO (Community And Systems-level INteractive Optimization) toolbox is described, a comprehensive computational platform for analysis of microbial communities through metabolic modeling that could quantitatively describe altered fecal and serum amino acid levels in response to diet intervention.