Journal ArticleDOI
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Nathan Mathewson,Orr Ashenberg,Itay Tirosh,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Sascha Marx,Livnat Jerby-Arnon,Rony Chanoch-Myers,Toshiro Hara,Toshiro Hara,Alyssa R. Richman,Alyssa R. Richman,Yoshinaga Ito,Jason Pyrdol,Mirco Friedrich,Kathrin Schumann,Kathrin Schumann,Michael J. Poitras,Prafulla C. Gokhale,L. Nicolas Gonzalez Castro,Marni E. Shore,Marni E. Shore,Christine M. Hebert,Christine M. Hebert,Brian A. Shaw,Heather L. Cahill,Matthew Drummond,Wubing Zhang,Olamide Olawoyin,Hiroaki Wakimoto,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Priscilla K. Brastianos,X. Shirley Liu,Pamela S. Jones,Daniel P. Cahill,Matthew P. Frosch,David N. Louis,Gordon J. Freeman,Keith L. Ligon,Alexander Marson,Alexander Marson,E. Antonio Chiocca,David A. Reardon,David A. Reardon,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Kai W. Wucherpfennig +49 more
TLDR
In this paper, single-cell RNA sequencing (RNA-seq) was used to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma.About:
This article is published in Cell.The article was published on 2021-03-04. It has received 160 citations till now. The article focuses on the topics: Cytotoxic T cell & KLRB1.read more
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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Toshiro Hara,Rony Chanoch-Myers,Nathan Mathewson,Nathan Mathewson,Chad Myskiw,Lyla Atta,Lillian Bussema,Lillian Bussema,Stephen W. Eichhorn,Stephen W. Eichhorn,Alissa C. Greenwald,Gabriela Sarti Kinker,Gabriela Sarti Kinker,Christopher Rodman,L. Nicolas Gonzalez Castro,Hiroaki Wakimoto,Orit Rozenblatt-Rosen,Xiaowei Zhuang,Xiaowei Zhuang,Jean Fan,Tony Hunter,Inder M. Verma,Kai W. Wucherpfennig,Kai W. Wucherpfennig,Aviv Regev,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Itay Tirosh +28 more
TL;DR: In this paper, the mesenchymal subtype of glioblastoma is determined by both cancer cell-intrinsic alterations and extrinsic cellular interactions, but remains poorly understood.
Journal ArticleDOI
Glioma targeted therapy: insight into future of molecular approaches
Keyang Yang,Zhijing Wu,Hao Zhang,Nan Zhang,Wantao Wu,Zeyu Wang,Xun Zhang,Liyang Zhang,Yu Peng,Wei-Jie Ye,Wen-Jing Zeng,Zhixiong Liu,Quan Cheng +12 more
TL;DR: In this article , the authors discuss novel feasible or potential targets for treatment of gliomas, especially IDH-wild type glioblastoma, and evaluate the feasibility of targeted therapy with the corresponding biomarkers for effective personalized treatment options.
Journal ArticleDOI
Glioma targeted therapy: insight into future of molecular approaches
Keyang Yang,Zhijing Wu,Hao Zhang,Nan Zhang,Wantao Wu,Zeyu Wang,Xun Zhang,Liyang Zhang,Yun Peng,Weijie Ye,Wen-Jing Zeng,Zhixiong Liu,Quan Cheng +12 more
TL;DR: In this article , the authors discuss novel feasible or potential targets for treatment of gliomas, especially IDH-wild type glioblastoma, and evaluate the feasibility of targeted therapy with the corresponding biomarkers for effective personalized treatment options.
Journal ArticleDOI
Applications of single-cell sequencing in cancer research: progress and perspectives
TL;DR: The use of single-cell sequencing in cancer research has revolutionized our understanding of the biological characteristics and dynamics within cancer lesions, including information related to the landscapes of malignant cells and immune cells, tumor heterogeneity, circulating tumor cells and underlying mechanisms of tumor biological behaviors as mentioned in this paper.
Journal ArticleDOI
An NK-like CAR T cell transition in CAR T cell dysfunction.
Charly R. Good,M. Angela Aznar,Shunichiro Kuramitsu,Parisa Samareh,Sangya Agarwal,Greg Donahue,Kenichi Ishiyama,Nils Wellhausen,Austin K. Rennels,Yujie Ma,Lifeng Tian,Sonia Guedan,Katherine A. Alexander,Zhen Zhang,Philipp C. Rommel,Nathan Singh,Karl M. Glastad,Max W. Richardson,Keisuke Watanabe,Janos L. Tanyi,Mark H. O'Hara,Marco Ruella,Simon F. Lacey,Edmund K. Moon,Stephen J. Schuster,Steven M. Albelda,Lewis L. Lanier,Regina M. Young,Shelley L. Berger,Carl H. June +29 more
TL;DR: In this article, the authors established a robust model of continuous antigen exposure that recapitulates hallmark features of T-cell exhaustion and found that CAR dysregulation is associated with a CD8+ T-to-NK-like Tcell transition.
References
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TL;DR: Bowtie extends previous Burrows-Wheeler techniques with a novel quality-aware backtracking algorithm that permits mismatches and can be used simultaneously to achieve even greater alignment speeds.
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Fast unfolding of communities in large networks
Vincent D. Blondel,Jean-Loup Guillaume,Jean-Loup Guillaume,Renaud Lambiotte,Renaud Lambiotte,Etienne Lefebvre +5 more
TL;DR: In this paper, the authors proposed a simple method to extract the community structure of large networks based on modularity optimization, which is shown to outperform all other known community detection methods in terms of computation time.
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Integrating single-cell transcriptomic data across different conditions, technologies, and species.
TL;DR: An analytical strategy for integrating scRNA-seq data sets based on common sources of variation is introduced, enabling the identification of shared populations across data sets and downstream comparative analysis.
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