M
Michael Bachmann
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 402
Citations - 16252
Michael Bachmann is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Antigen & Chimeric antigen receptor. The author has an hindex of 63, co-authored 360 publications receiving 14388 citations. Previous affiliations of Michael Bachmann include ACADIA Pharmaceuticals Inc. & University of Southern California.
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Advances in In Vivo Bioluminescence Imaging of Gene Expression
TL;DR: In vivo bioluminescence imaging has been combined with in vivo fluorescence imaging methods, which has enabled the real-time study of immune cell trafficking, of various genetic regulatory elements in transgenic mice, and of in vivo gene transfer.
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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Catherine M. Shachaf,Andrew M. Kopelman,Constadina Arvanitis,Asa Karlsson,Shelly Beer,Stefanie Mandl,Michael Bachmann,Alexander D. Borowsky,Boris H. Ruebner,Robert D. Cardiff,Qiwei Yang,J. Michael Bishop,Christopher H. Contag,Dean W. Felsher +13 more
TL;DR: It is reported that inactivation of the MYC oncogene is sufficient to induce sustained regression of invasive liver cancers and how oncogenic inactivation may reverse tumorigenesis in the most clinically difficult cancers is shown.
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Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
TL;DR: Co-transduced T cells destroy tumors that express both antigens but do not affect tumors expressing either antigen alone, and this 'tumor-sensing' strategy may help broaden the applicability and avoid some of the side effects of targeted T-cell therapies.
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Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models
Huiping Liu,Manishkumar Patel,Jennifer A. Prescher,Antonia Patsialou,Dalong Qian,Jiahui Lin,Susanna Wen,Ya Fang Chang,Ya Fang Chang,Michael Bachmann,Yohei Shimono,Piero Dalerba,Maddalena Adorno,Neethan A. Lobo,Janet Bueno,Frederick M. Dirbas,Sumanta Goswami,George Somlo,John S. Condeelis,Christopher H. Contag,Sanjiv S. Gambhir,Michael F. Clarke +21 more
TL;DR: These metastatic cancer models, combined with noninvasive imaging techniques, constitute an integrated approach that could be applied to dissect the molecular mechanisms underlying the dissemination of metastatic CSCs (MCSCs) and to explore therapeutic strategies targeting MCSCs in general or to evaluate individual patient tumor cells and predict response to therapy.
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Differential fates of biomolecules delivered to target cells via extracellular vesicles
Masamitsu Kanada,Michael Bachmann,Jonathan Hardy,Daniel Omar Frimannson,Laura L. Bronsart,Andrew Wang,Matthew D. Sylvester,Tobi L. Schmidt,Roger L. Kaspar,Manish J. Butte,Abdul Matin,Christopher H. Contag +11 more
TL;DR: It is observed that only microvesicles (MVs) can functionally transfer loaded reporter molecules to recipient cells, largely by delivering plasmid DNA, and that exosomes and MVs are structurally and functionally distinct.