T
Tim Magnus
Researcher at University of Hamburg
Publications - 154
Citations - 7001
Tim Magnus is an academic researcher from University of Hamburg. The author has contributed to research in topics: Microglia & Inflammation. The author has an hindex of 38, co-authored 133 publications receiving 5338 citations. Previous affiliations of Tim Magnus include Hamburg University of Technology & Eppendorf (Germany).
Papers
More filters
Journal ArticleDOI
Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Mathias Gelderblom,Frank Leypoldt,Karin Steinbach,Doerthe Behrens,Chi-Un Choe,Dominic A. Siler,Thiruma V. Arumugam,Ellen Orthey,Christian Gerloff,Eva Tolosa,Tim Magnus +10 more
TL;DR: The peculiar activation pattern and massive increase of antigen-presenting cells in temporal conjunction with regulatory cells might provide additional insight into poststroke immune regulation.
Journal ArticleDOI
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
Yang-Wei Fann,S-Y Lee,Silvia Manzanero,Sung-Chun Tang,Mathias Gelderblom,Prasad Chunduri,Christian Bernreuther,Markus Glatzel,Yi-Lin Cheng,John Thundyil,Alexander Widiapradja,Ker Zhing Lok,S L Foo,Y-C Wang Wang,Y-I Li,Grant R Drummond,Milan Basta,Tim Magnus,Dong-Gyu Jo,Mark P. Mattson,Christopher G. Sobey,Thiruma V. Arumugam,Thiruma V. Arumugam,Thiruma V. Arumugam +23 more
TL;DR: Evidence is provided that the NLRP1 and NLRP3 inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke, and that IVIg treatment can protect brain cells against ischemic damage, suggesting a potential clinical benefit of therapeutic interventions that targetinflammasome assembly and activity.
Journal ArticleDOI
Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke.
Mathias Gelderblom,Anna Weymar,Christian Bernreuther,Joachim Velden,Priyadharshini Arunachalam,Karin Steinbach,Ellen Orthey,Thiruma V. Arumugam,Frank Leypoldt,Olga Simova,Vivien Thom,Manuel A. Friese,Immo Prinz,Christoph Hölscher,Markus Glatzel,Thomas Korn,Christian Gerloff,Eva Tolosa,Tim Magnus +18 more
TL;DR: It is proposed that selective targeting of IL-17A signaling might provide a new therapeutic option for the treatment of stroke, and this aspect of the inflammatory cascade is also relevant in the human brain.
Journal ArticleDOI
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
Christoph Kleinschnitz,Peter Kraft,Angela Dreykluft,Ina Hagedorn,Kerstin Göbel,Michael K. Schuhmann,Friederike Langhauser,Xavier Helluy,Tobias Schwarz,Stefan Bittner,Christian T. Mayer,Marc Brede,Csanad Varallyay,Mirko Pham,Martin Bendszus,Peter M. Jakob,Tim Magnus,Sven G. Meuth,Yoichiro Iwakura,Alma Zernecke,Tim Sparwasser,Bernhard Nieswandt,Guido Stoll,Heinz Wiendl +23 more
TL;DR: A novel and unexpected role of Tregs in a primary nonimmunologic disease state is defined, which reduced microvascular thrombus formation and improved cerebral reperfusion on stroke, as revealed by ultra-high-field magnetic resonance imaging at 17.6 Tesla.
Journal ArticleDOI
Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death
Thiruma V. Arumugam,Sung-Chun Tang,Justin D. Lathia,Aiwu Cheng,Mohamed R. Mughal,Srinivasulu Chigurupati,Tim Magnus,Sic L. Chan,Dong-Gyu Jo,Xin Ouyang,David P. Fairlie,Daniel N. Granger,Alexander O. Vortmeyer,Milan Basta,Mark P. Mattson +14 more
TL;DR: A major role for complement-mediated cell death in ischemic brain injury is suggested and the prospect of using IVIG in relatively low doses as an interventional therapy for stroke is suggested.