U
Uwe Weierstall
Researcher at Arizona State University
Publications - 161
Citations - 16208
Uwe Weierstall is an academic researcher from Arizona State University. The author has contributed to research in topics: Diffraction & Femtosecond. The author has an hindex of 55, co-authored 158 publications receiving 14456 citations. Previous affiliations of Uwe Weierstall include Lawrence Berkeley National Laboratory & Lawrence Livermore National Laboratory.
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Journal ArticleDOI
Femtosecond X-ray protein nanocrystallography
Henry N. Chapman,Petra Fromme,Anton Barty,Thomas A. White,Richard A. Kirian,Andrew Aquila,Mark S. Hunter,Joachim Schulz,Daniel P. DePonte,Uwe Weierstall,R. Bruce Doak,Filipe R. N. C. Maia,Andrew V. Martin,Ilme Schlichting,Lukas Lomb,Nicola Coppola,Robert L. Shoeman,Sascha W. Epp,Robert Hartmann,Daniel Rolles,Artem Rudenko,Lutz Foucar,Nils Kimmel,Georg Weidenspointner,Peter Holl,Mengning Liang,Miriam Barthelmess,Carl Caleman,Sébastien Boutet,Michael J. Bogan,Jacek Krzywinski,Christoph Bostedt,Saša Bajt,Lars Gumprecht,Benedikt Rudek,Benjamin Erk,Carlo Schmidt,André Hömke,Christian Reich,Daniel Pietschner,Lothar Strüder,Günter Hauser,H. Gorke,Joachim Ullrich,Sven Herrmann,Gerhard Schaller,Florian Schopper,Heike Soltau,Kai-Uwe Kühnel,Marc Messerschmidt,John D. Bozek,Stefan P. Hau-Riege,Matthias Frank,Christina Y. Hampton,Raymond G. Sierra,Dmitri Starodub,Garth J. Williams,Janos Hajdu,Nicusor Timneanu,M. Marvin Seibert,M. Marvin Seibert,Jakob Andreasson,Andrea Rocker,Olof Jönsson,Martin Svenda,Stephan Stern,Karol Nass,Robert Andritschke,Claus Dieter Schröter,Faton Krasniqi,Mario Bott,Kevin Schmidt,Xiaoyu Wang,Ingo Grotjohann,James M. Holton,Thomas R. M. Barends,Richard Neutze,Stefano Marchesini,Raimund Fromme,Sebastian Schorb,Daniela Rupp,M. Adolph,Tais Gorkhover,Inger Andersson,Helmut Hirsemann,Guillaume Potdevin,Heinz Graafsma,Björn Nilsson,John C. H. Spence +88 more
TL;DR: This work offers a new approach to structure determination of macromolecules that do not yield crystals of sufficient size for studies using conventional radiation sources or are particularly sensitive to radiation damage, by using pulses briefer than the timescale of most damage processes.
Journal ArticleDOI
Single mimivirus particles intercepted and imaged with an X-ray laser
M. Marvin Seibert,Tomas Ekeberg,Filipe R. N. C. Maia,Martin Svenda,Jakob Andreasson,Olof Jönsson,Dusko Odic,Bianca Iwan,Andrea Rocker,Daniel Westphal,Max F. Hantke,Daniel P. DePonte,Anton Barty,Joachim Schulz,Lars Gumprecht,Nicola Coppola,Andrew Aquila,Mengning Liang,Thomas A. White,Andrew V. Martin,Carl Caleman,Stephan Stern,Chantal Abergel,Virginie Seltzer,Jean-Michel Claverie,Christoph Bostedt,John D. Bozek,Sébastien Boutet,A. Miahnahri,Marc Messerschmidt,Jacek Krzywinski,Garth J. Williams,Keith O. Hodgson,Michael J. Bogan,Christina Y. Hampton,Raymond G. Sierra,D. Starodub,Inger Andersson,Sǎa Bajt,Miriam Barthelmess,John C. H. Spence,Petra Fromme,Uwe Weierstall,Richard A. Kirian,Mark S. Hunter,R. Bruce Doak,Stefano Marchesini,Stefan P. Hau-Riege,Matthias Frank,Robert L. Shoeman,Lukas Lomb,Sascha W. Epp,Robert Hartmann,Daniel Rolles,Artem Rudenko,Carlo Schmidt,Lutz Foucar,Nils Kimmel,Peter Holl,Benedikt Rudek,Benjamin Erk,André Hömke,Christian Reich,Daniel Pietschner,Georg Weidenspointner,Lothar Strüder,Günter Hauser,H. Gorke,Joachim Ullrich,Ilme Schlichting,Sven Herrmann,Gerhard Schaller,Florian Schopper,Heike Soltau,Kai Uwe Kuhnel,Robert Andritschke,Claus Dieter Schröter,Faton Krasniqi,Mario Bott,Sebastian Schorb,Daniela Rupp,M. Adolph,Tais Gorkhover,Helmut Hirsemann,Guillaume Potdevin,Heinz Graafsma,Björn Nilsson,Henry N. Chapman,Janos Hajdu +88 more
TL;DR: This work shows that high-quality diffraction data can be obtained with a single X-ray pulse from a non-crystalline biological sample, a single mimivirus particle, which was injected into the pulsed beam of a hard-X-ray free-electron laser, the Linac Coherent Light Source.
Journal ArticleDOI
X-ray image reconstruction from a diffraction pattern alone
Stefano Marchesini,H. He,Henry N. Chapman,Stefan P. Hau-Riege,Aleksandr Noy,Malcolm R. Howells,Uwe Weierstall,John C. H. Spence +7 more
TL;DR: In this article, an inversion method was used to reconstruct the image of the object without the need for any such prior knowledge, without the knowledge of the shape of the objects and the low spatial frequencies unavoidably lost in experiments.
Journal ArticleDOI
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography
Sébastien Boutet,Lukas Lomb,Garth J. Williams,Thomas R. M. Barends,Andrew Aquila,R. Bruce Doak,Uwe Weierstall,Daniel P. DePonte,Jan Steinbrener,Robert L. Shoeman,Marc Messerschmidt,Anton Barty,Thomas A. White,Stephan Kassemeyer,Richard A. Kirian,M. Marvin Seibert,Paul A. Montanez,C.J. Kenney,Ryan Herbst,P. Hart,J. Pines,Gunther Haller,Sol M. Gruner,Hugh T. Philipp,Mark W. Tate,Marianne Hromalik,Lucas J. Koerner,Niels van Bakel,John Morse,W. Ghonsalves,David Arnlund,Michael J. Bogan,Carl Caleman,Raimund Fromme,Christina Y. Hampton,Mark S. Hunter,Linda C. Johansson,Gergely Katona,Christopher Kupitz,Mengning Liang,Andrew V. Martin,Karol Nass,Lars Redecke,Lars Redecke,Francesco Stellato,Nicusor Timneanu,Dingjie Wang,Nadia A. Zatsepin,Donald W. Schafer,James Defever,Richard Neutze,Petra Fromme,John C. H. Spence,Henry N. Chapman,Ilme Schlichting +54 more
TL;DR: Serial femtosecond crystallography (SFX) is applied using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals of the well-characterized model protein lysozyme, demonstrating the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.
Journal ArticleDOI
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang,X. Edward Zhou,Xiang Gao,Yuanzheng He,Wei Liu,Andrii Ishchenko,Anton Barty,Thomas A. White,Oleksandr Yefanov,Gye Won Han,Qingping Xu,Parker W. de Waal,Jiyuan Ke,M. H. Eileen Tan,Chenghai Zhang,Arne Moeller,Graham M. West,Bruce D. Pascal,Ned Van Eps,Lydia N. Caro,Sergey A. Vishnivetskiy,Regina J. Lee,Kelly Suino-Powell,Xin Gu,Kuntal Pal,Jinming Ma,Xiaoyong Zhi,Sébastien Boutet,Garth J. Williams,Marc Messerschmidt,Cornelius Gati,Nadia A. Zatsepin,Dingjie Wang,Daniel James,Shibom Basu,Shatabdi Roy-Chowdhury,Chelsie E. Conrad,Jesse Coe,Haiguang Liu,Stella Lisova,Christopher Kupitz,Ingo Grotjohann,Raimund Fromme,Yi Jiang,Minjia Tan,Huaiyu Yang,Jun Li,Meitian Wang,Zhong Zheng,Dianfan Li,Nicole Howe,Yingming Zhao,Jörg Standfuss,Kay Diederichs,Yuhui Dong,Clinton S. Potter,Bridget Carragher,Martin Caffrey,Hualiang Jiang,Henry N. Chapman,John C. H. Spence,Petra Fromme,Uwe Weierstall,Oliver P. Ernst,Vsevolod Katritch,Vsevolod V. Gurevich,Patrick R. Griffin,Wayne L. Hubbell,Raymond C. Stevens,Vadim Cherezov,Karsten Melcher,H. Eric Xu +71 more
TL;DR: The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.