Victor M. Corman

TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.

TL;DR: Detailed virological analysis of nine cases of coronavirus disease 2019 (COVID-19) provides proof of active replication of the SARS-CoV-2 virus in tissues of the upper respiratory tract.

TL;DR: It is demonstrated that most PCR-confirmed SARS-CoV-2–infected persons seroconverted by 2 weeks after disease onset, and validated and tested various antigens in different in-house and commercial ELISAs, finding that commercial S1 IgG or IgA ELISA were of lower specificity, and sensitivity varied between the 2 assays; the IgAELISA showed higher sensitivity.

TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

TL;DR: CD4 + T cells that are reactive against the spike glycoprotein of SARS-CoV-2 in the peripheral blood of patients with COVID-19 and healthy donors are found, indicating that spike-protein cross-reactive T cells are present and probably generated during previous encounters with endemic coronaviruses.