Y
Yves Pommier
Researcher at National Institutes of Health
Publications - 847
Citations - 65543
Yves Pommier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 123, co-authored 789 publications receiving 58898 citations. Previous affiliations of Yves Pommier include Purdue University & Kyushu University.
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Topoisomerase I inhibitors : camptothecins and beyond
TL;DR: The mechanisms and molecular determinants of tumour response to TOP1 inhibitor are reviewed, and rational combinations of TOP1 inhibitors with other drugs are considered based on current knowledge of repair and checkpoint pathways that are associated with TOP1-mediated DNA damage.
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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Junko Murai,Shar Yin N. Huang,Benu Brata Das,Amelie Renaud,Yiping Zhang,James H. Doroshow,Jiuping Ji,Shunichi Takeda,Yves Pommier +8 more
TL;DR: This study shows that PARP inhibitors trap the PARP1 and PARP2 enzymes at damaged DNA, providing a new mechanistic foundation for the rational application ofPARP inhibitors in cancer therapy.
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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.
TL;DR: This review focuses on the molecular and biochemical characteristics of topoisomerases and their inhibitors and discusses the common mechanism of action ofTopoisomerase poisons by interfacial inhibition and trapping of topisomerase cleavage complexes.
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A gene expression database for the molecular pharmacology of cancer
Uwe Scherf,Douglas T. Ross,Mark Waltham,Lawrence H. Smith,Jae K. Lee,Lorraine K. Tanabe,Kurt W. Kohn,William C. Reinhold,Timothy G. Myers,Darren T. Andrews,Dominic A. Scudiero,Michael B. Eisen,Edward A. Sausville,Yves Pommier,David Botstein,Patrick O. Brown,John N. Weinstein +16 more
TL;DR: Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance.
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γH2AX and cancer
William M. Bonner,Christophe E. Redon,Jennifer S. Dickey,Asako J. Nakamura,Olga A. Sedelnikova,Stéphanie Solier,Yves Pommier +6 more
TL;DR: In this paper, the authors used histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing gammaH2AX) as a sensitive marker for DNA double-strand breaks (DSBs).