Institution
Broad Institute
Nonprofit•Cambridge, Massachusetts, United States•
About: Broad Institute is a nonprofit organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 6584 authors who have published 11618 publications receiving 1522743 citations. The organization is also known as: Eli and Edythe L. Broad Institute of MIT and Harvard.
Papers published on a yearly basis
Papers
More filters
Johns Hopkins University1, Ludwig Institute for Cancer Research2, Max Planck Society3, Novartis4, Cancer Research UK5, Wellcome Trust Sanger Institute6, Broad Institute7, Harvard University8, Merck & Co.9, University of California, San Diego10, University of Texas Southwestern Medical Center11, Massachusetts Institute of Technology12, University of Helsinki13, Howard Hughes Medical Institute14, Netherlands Cancer Institute15
TL;DR: This Commentary is an invitation to an open discussion started among various users of RNAi to set forth accepted standards that would insure the quality and accuracy of information in the large datasets coming out of genome-scale screens.
Abstract: Large-scale RNA interference (RNAi)-based analyses, very much as other ‘omic’ approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to validate results from these studies, if left unchecked, could eventually begin to undermine the credibility of RNAi as a powerful functional approach. This Commentary is an invitation to an open discussion started among various users of RNAi to set forth accepted standards that would insure the quality and accuracy of information in the large datasets coming out of genome-scale screens.
462 citations
Beth Israel Deaconess Medical Center1, Harvard University2, National University of Singapore3, Massachusetts Institute of Technology4, Broad Institute5, New England Biolabs6, University of Michigan7, Academy of Sciences of the Czech Republic8, Catholic University of the Sacred Heart9, Cornell University10
TL;DR: Data is presented demonstrating that active transcription regulates levels of genomic methylation and a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile is identified.
Abstract: DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data demonstrating that active transcription regulates levels of genomic methylation. We identify a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile. This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. Deep sequencing of transcripts associated with DNMT1 combined with genome-scale methylation and expression profiling extend the generality of this finding to numerous gene loci. Collectively, these results delineate the nature of DNMT1-RNA interactions and suggest strategies for gene-selective demethylation of therapeutic targets in human diseases.
461 citations
TL;DR: In this article, the authors introduced genome-wide pooled CRISPR-Cas9 libraries into dendritic cells (DCs) to identify genes that control the induction of tumor necrosis factor (Tnf) by bacterial lipopolysaccharide (LPS), a key process in the host response to pathogens, mediated by the Tlr4 pathway.
460 citations
TL;DR: In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors, and β-aminoisobutyric acid (BAIBA) may contribute to exercise-induced protection from metabolic diseases.
460 citations
TL;DR: In this paper, whole-exome sequencing of circulating tumor cells enables accurate and powered calling of somatic point mutations, and the authors propose a method to identify the source of the point mutations.
Abstract: Whole-exome sequencing of circulating tumor cells enables accurate and powered calling of somatic point mutations.
459 citations
Authors
Showing all 7146 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric S. Lander | 301 | 826 | 525976 |
| Albert Hofman | 267 | 2530 | 321405 |
| Frank B. Hu | 250 | 1675 | 253464 |
| David J. Hunter | 213 | 1836 | 207050 |
| Kari Stefansson | 206 | 794 | 174819 |
| Mark J. Daly | 204 | 763 | 304452 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Matthew Meyerson | 194 | 553 | 243726 |
| Gad Getz | 189 | 520 | 247560 |
| Stacey Gabriel | 187 | 383 | 294284 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Ralph Weissleder | 184 | 1160 | 142508 |
| Chris Sander | 178 | 713 | 233287 |
| Michael I. Jordan | 176 | 1016 | 216204 |
| Richard A. Young | 173 | 520 | 126642 |