Institution
Broad Institute
Nonprofit•Cambridge, Massachusetts, United States•
About: Broad Institute is a nonprofit organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Genome-wide association study. The organization has 6584 authors who have published 11618 publications receiving 1522743 citations. The organization is also known as: Eli and Edythe L. Broad Institute of MIT and Harvard.
Papers published on a yearly basis
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TL;DR: The present Bioconda, a distribution of bioinformatics software for the lightweight, multi-platform and language-agnostic package manager Conda, improves analysis reproducibility by allowing users to define isolated environments with defined software versions.
Abstract: We present Bioconda (https://bioconda.github.io), a distribution of bioinformatics software for the lightweight, multi-platform and language-agnostic package manager Conda. Currently, Bioconda offers a collection of over 3000 software packages, which is continuously maintained, updated, and extended by a growing global community of more than 200 contributors. Bioconda improves analysis reproducibility by allowing users to define isolated environments with defined software versions, all of which are easily installed and managed without administrative privileges.
699 citations
TL;DR: It is proposed that cells contain several mTORC2 flavors that may phosphorylate Akt/PKB in response to different signals.
698 citations
TL;DR: In this paper, the authors develop Ψ-seq for transcriptome-wide quantitative mapping of pseudouridine and identify hundreds of unique sites in human and yeast mRNAs and snoRNAs.
697 citations
TL;DR: In this article, the authors present CRISPResso2 to analyze base editors, perform allele-specific quantification or incorporate biologically-informed and scalable alignment approaches, and demonstrate its functionality by experimentally measuring and analyzing the editing properties of six genome editing agents.
Abstract: Genome editing technologies are rapidly evolving, and analysis of deep sequencing data from target or off-target regions is necessary for measuring editing efficiency and evaluating safety. However, no software exists to analyze base editors, perform allele-specific quantification or that incorporates biologically-informed and scalable alignment approaches. Here, we present CRISPResso2 to fill this gap and illustrate its functionality by experimentally measuring and analyzing the editing properties of six genome editing agents.
696 citations
Broad Institute1, Whitman College2, Simon Fraser University3, Howard Hughes Medical Institute4, University of Coimbra5, University College Dublin6, Emory University7, Chinese Academy of Sciences8, University of Ferrara9, University of Miskolc10, Armenian National Academy of Sciences11, University of Pennsylvania12, University of Winnipeg13, Alexandru Ioan Cuza University14, University of Edinburgh15, Royal College of Surgeons in Ireland16, Spanish National Research Council17, Imperial College London18, Max Planck Society19, Binghamton University20, University of Huddersfield21, University of Pavia22, Yerevan State University23
TL;DR: This paper reported genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 bc, from Natufian hunter-gatherers to Bronze Age farmers, showing that the earliest populations of the Near East derived around half their ancestry from a 'Basal Eurasian' lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other.
Abstract: We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 bc, from Natufian hunter–gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a ‘Basal Eurasian’ lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local hunter–gatherers. By the time of the Bronze Age, these two populations and Anatolian-related farmers had mixed with each other and with the hunter–gatherers of Europe to greatly reduce genetic differentiation. The impact of the Near Eastern farmers extended beyond the Near East: farmers related to those of Anatolia spread westward into Europe; farmers related to those of the Levant spread southward into East Africa; farmers related to those of Iran spread northward into the Eurasian steppe; and people related to both the early farmers of Iran and to the pastoralists of the Eurasian steppe spread eastward into South Asia.
695 citations
Authors
Showing all 7146 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric S. Lander | 301 | 826 | 525976 |
| Albert Hofman | 267 | 2530 | 321405 |
| Frank B. Hu | 250 | 1675 | 253464 |
| David J. Hunter | 213 | 1836 | 207050 |
| Kari Stefansson | 206 | 794 | 174819 |
| Mark J. Daly | 204 | 763 | 304452 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Matthew Meyerson | 194 | 553 | 243726 |
| Gad Getz | 189 | 520 | 247560 |
| Stacey Gabriel | 187 | 383 | 294284 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Ralph Weissleder | 184 | 1160 | 142508 |
| Chris Sander | 178 | 713 | 233287 |
| Michael I. Jordan | 176 | 1016 | 216204 |
| Richard A. Young | 173 | 520 | 126642 |