Institution
Casa Sollievo della Sofferenza
Healthcare•San Giovanni Rotondo, Italy•
About: Casa Sollievo della Sofferenza is a healthcare organization based out in San Giovanni Rotondo, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 2234 authors who have published 6183 publications receiving 239811 citations. The organization is also known as: Home for Relief of the Suffering.
Topics: Population, Cancer, Gene, Diabetes mellitus, Type 2 diabetes
Papers published on a yearly basis
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Leiden University1, Harvard University2, Utrecht University3, Massachusetts Institute of Technology4, University of Groningen5, Queen Mary University of London6, Drug Abuse Resistance Education7, Trinity College, Dublin8, University Medical Center Groningen9, National Institutes of Health10, University of Naples Federico II11, Leiden University Medical Center12, Casa Sollievo della Sofferenza13, Sapienza University of Rome14, Radboud University Nijmegen Medical Centre15, Celera Corporation16, North Shore-LIJ Health System17, University of Manchester18, University of Toronto19, Karolinska University Hospital20
TL;DR: A meta-analysis of two published GWAS on celiac disease and rheumatoid arthritis confirmed that 4 gene loci previously established in either CD or RA are associated with the other autoimmune disease at combined P<5×10−8, and implicate antigen presentation and T-cell activation as a shared mechanism of disease pathogenesis.
Abstract: Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-HLA CD and RA risk loci (out of 26 loci for each disease) are shared between both diseases. We hypothesized that there are additional shared risk alleles and that combining genome-wide association study (GWAS) data from each disease would increase power to identify these shared risk alleles. We performed a meta-analysis of two published GWAS on CD (4,533 cases and 10,750 controls) and RA (5,539 cases and 17,231 controls). After genotyping the top associated SNPs in 2,169 CD cases and 2,255 controls, and 2,845 RA cases and 4,944 controls, 8 additional SNPs demonstrated P,5610 28 in a combined analysis of all 50,266 samples, including four SNPs that have not been previously confirmed in either disease: rs10892279 near the DDX6 gene (Pcombined=1.2610 212 ), rs864537 near CD247 (Pcombined=2.2610 211 ), rs2298428 near UBE2L3 (Pcombined=2.5610 210 ), and rs11203203 near UBASH3A (Pcombined =1.1610 28 ). We also confirmed that 4 gene loci previously established in either CD or RA are associated with the other autoimmune disease at combined P,5610 28 (SH2B3, 8q24, STAT4, and TRAF1-C5). From the 14 shared gene loci, 7 SNPs showed a genome-wide significant effect on expression of one or more transcripts in the linkage disequilibrium (LD) block around the SNP. These associations implicate antigen presentation and T-cell activation as a shared mechanism of disease pathogenesis and underscore the utility of cross-disease meta-analysis for identification of genetic risk factors with pleiotropic effects between two clinically distinct diseases.
312 citations
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TL;DR: Oral MPR therapy is a promising first-line treatment for elderly myeloma patients and aspirin appears to provide adequate antithrombosis prophylaxis.
Abstract: Purpose Lenalidomide has shown significant antimyeloma activity in clinical studies. Oral melphalan, prednisone, and thalidomide have been regarded as the standard of care in elderly multiple myeloma patients. We assessed dosing, efficacy, and safety of melphalan, prednisone, and lenalidomide (MPR) in newly diagnosed elderly myeloma patients. Patients and Methods Oral melphalan was administered in doses ranging from 0.18 to 0.25 mg/kg on days 1 to 4, prednisone at a 2-mg/kg dose on days 1 to 4, and lenalidomide at doses ranging from 5 to 10 mg on days 1 to 21, every 28 days for nine cycles, followed by maintenance therapy with lenalidomide alone. Aspirin was given as a prophylaxis for thrombosis. Results Fifty-four patients were enrolled and evaluated after completing the assigned treatment schedule. The maximum tolerated dose was defined as 0.18 mg/kg melphalan and 10 mg lenalidomide. With these doses, 81% of patients achieved at least a partial response, 47.6% achieved a very good partial response, and ...
312 citations
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TL;DR: The hybrid AF ablation strategy including antrum isolation and CFAE ablation had the highest likelihood of maintaining sinus rhythm in patients with longstanding permanent AF.
310 citations
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Wellcome Trust Sanger Institute1, University of Oslo2, Oslo University Hospital3, University of Kiel4, Norwich University5, Max Planck Society6, University of Groningen7, Hannover Medical School8, University of Calgary9, University of Toronto10, National Institute for Health Research11, University of Barcelona12, Mayo Clinic13, Pomeranian Medical University14, Ludwig Maximilian University of Munich15, University of Hamburg16, Charité17, University of Cambridge18, University of Thessaly19, University of Bonn20, Technische Universität München21, University of California, Berkeley22, University of Mainz23, University of Alberta24, University of Helsinki25, National Institutes of Health26, Sapienza University of Rome27, University of Padua28, University of Virginia29, University of California, San Diego30, University of Lübeck31, Norwegian University of Science and Technology32, Katholieke Universiteit Leuven33, Queen Mary University of London34, Akershus University Hospital35, Mount Sinai Hospital, Toronto36, University of Pittsburgh37, Karolinska University Hospital38, Casa Sollievo della Sofferenza39, Cleveland Clinic Lerner Research Institute40, Cleveland Clinic41, University of Paris42, University of California, Davis43, Montreal Heart Institute44, Université de Montréal45, Yale University46
TL;DR: This analysis compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip to identify 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16.
Abstract: Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.
309 citations
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TL;DR: The prevalence of asymptomatic vertebral fractures in a large sample of post-menopausal women given GCs for different diseases was much higher than that found in epidemiological studies on healthy women and clearly increased with age.
306 citations
Authors
Showing all 2237 results
Name | H-index | Papers | Citations |
---|---|---|---|
Ralph B. D'Agostino | 226 | 1287 | 229636 |
Cisca Wijmenga | 136 | 668 | 86572 |
Massimo Mangino | 116 | 369 | 84902 |
Xavier Estivill | 110 | 673 | 59568 |
Andrea Natale | 106 | 945 | 52520 |
Stefano Pileri | 100 | 635 | 43369 |
Bruno Dallapiccola | 94 | 935 | 43208 |
Fortunato Ciardiello | 94 | 695 | 47352 |
F. Bianchi | 91 | 1370 | 40011 |
Paolo Gasparini | 91 | 431 | 36059 |
Joseph G. Gleeson | 86 | 307 | 23345 |
Mario Rizzetto | 79 | 470 | 33693 |
Giuseppe Leone | 74 | 654 | 21451 |
Maurizio Pompili | 74 | 783 | 20649 |
Massimo Rugge | 74 | 594 | 25624 |