Institution
Cochin University of Science and Technology
Education•Kochi, Kerala, India•
About: Cochin University of Science and Technology is a education organization based out in Kochi, Kerala, India. It is known for research contribution in the topics: Thin film & Natural rubber. The organization has 5382 authors who have published 7690 publications receiving 103827 citations. The organization is also known as: CUSAT & Cochin University.
Topics: Thin film, Natural rubber, Dielectric, Catalysis, Microstrip antenna
Papers published on a yearly basis
Papers
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TL;DR: Results demonstrate that the miR-21-PDCD4 signaling axis plays an important role in Cr(VI)-induced carcinogenesis and reduces the tumorogenicity of chronic Cr( VI)-exposed BEAS-2B cells in nude mice.
Abstract: Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with an increased risk of lung cancer. However, the mechanisms underlying Cr(VI)-induced carcinogenesis remain unclear. MicroRNA-21 (miR-21) is a key regulator of oncogenic processes. Studies have shown that miR-21 exerts its oncogenic activity by targeting the tumor suppressor gene programmed cell death 4 (PDCD4). The present study examined the role of miR-21-PDCD4 signaling in Cr(VI)-induced cell transformation and tumorigenesis. Results showed that Cr(VI) induces ROS generation in human bronchial epithelial (BEAS-2B) cells. Chronic exposure to Cr(VI) is able to cause malignant transformation in BEAS-2B cells. Cr(VI) caused a significant increase of miR-21 expression associated with an inhibition of PDCD4 expression. Notably, STAT3 transcriptional activation by IL-6 is crucial for the Cr(VI)-induced miR-21 elevation. Stable knockdown of miR-21 or overexpression of PDCD4 in BEAS-2B cells significantly reduced the Cr(VI)-induced cell transformation. Furthermore, the Cr(VI) induced inhibition of PDCD4 suppressed downstream E-cadherin protein expression, but promoted β-catenin/TCF-dependent transcription of uPAR and c-Myc. We also found an increased miR-21 level and decreased PDCD4 expression in xenograft tumors generated with chronic Cr(VI)-exposed BEAS-2B cells. In addition, stable knockdown of miR-21 and overexpression of PDCD4 reduced the tumorogenicity of chronic Cr(VI)-exposed BEAS-2B cells in nude mice. Taken together, these results demonstrate that the miR-21-PDCD4 signaling axis plays an important role in Cr(VI)-induced carcinogenesis.
41 citations
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TL;DR: In this paper, two dicyanamide-interlaced tetranuclear Zn(II)-Schiff-base complexes were synthesized by using salicylaldimino type Schiff bases (H2LOMe) and H2LOEt) respectively.
41 citations
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Rockefeller University1, University of Paris2, Pennsylvania State University3, McGill University4, University of Cambridge5, Garvan Institute of Medical Research6, University of New South Wales7, Isfahan University of Medical Sciences8, Zanjan University of Medical Sciences9, Stanford University10, Tokyo Institute of Technology11, Qatar Airways12, German Cancer Research Center13, Katholieke Universiteit Leuven14, Thomas Jefferson University15, University of Southern California16, Cochin University of Science and Technology17, Ahvaz Jundishapur University of Medical Sciences18, Pasteur Institute19
TL;DR: In this paper, a patient with the human papilloma virus (HPV)-2-driven "treeman" phenotype and two relatives with unusually severe HPV4-driven warts were found to be unexpectedly homozygous for a private CD28 variant.
41 citations
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TL;DR: In this article, the authors highlight the enhanced crystallinity of polypyrrole films prepared from the redoped sample solution, which has drawn a lot of interest due to its high thermal and environmental stability in addition to high electrical conductivity.
41 citations
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TL;DR: In this article, a high permittivity dielectric resonator of suitable resonant frequency was loaded over the patch, and the % bandwidth of the antenna was increased by more than five times without much affecting its gain and radiation performance.
Abstract: A novel technique for the bandwidth enhancement of conventional rectangular microstrip antenna is proposed in this paper. When a high permittivity dielectric resonator of suitable resonant frequency was loaded over the patch, the % bandwidth of the antenna was increased by more than five times without much affecting its gain and radiation performance. A much more improved bandwidth was obtained when the dielectric resonator was placed on the feedline. Experimental study shows a 2:1 VSWR bandwidth of more than 10% and excellent cross polarization performance with increased pass band and radiation coverage almost the same as that of rectangular microstrip antenna. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 327–330, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10597
41 citations
Authors
Showing all 5433 results
Name | H-index | Papers | Citations |
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Pulickel M. Ajayan | 176 | 1223 | 136241 |
Maxime Dougados | 134 | 1054 | 69979 |
Sabu Thomas | 102 | 1554 | 51366 |
Philippe Ravaud | 101 | 618 | 41409 |
David P. Salmon | 99 | 419 | 43935 |
Jérôme Bertherat | 85 | 438 | 24794 |
Luc Mouthon | 84 | 564 | 26238 |
Xavier Bertagna | 74 | 285 | 18738 |
Alfred Mahr | 73 | 229 | 22581 |
Nicolas Roche | 72 | 629 | 22845 |
Charles Chapron | 71 | 378 | 18048 |
Benoit Terris | 61 | 234 | 13353 |
François Goffinet | 60 | 532 | 14433 |
Xavier Puéchal | 60 | 316 | 13240 |
Pascal Laugier | 58 | 482 | 10518 |