Emory University

About: Emory University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 51959 authors who have published 122469 publications receiving 6010698 citations.

Mild or Moderate Covid-19.

Abstract: Key Clinical Points Mild or Moderate Covid-19 Covid-19 (the illness caused by SARS-CoV-2) has a range of clinical manifestations, including cough, fever, malaise, myalgias, gastrointestinal symptom...

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

Abstract: Prenatal famine in humans has been associated with various later-life consequences, depending on the gestational timing of the insult and the sex of the exposed individual. Epigenetic mechanisms have been proposed to underlie these associations. Indeed, animal studies and our early human data on the imprinted IGF2 locus indicated a link between prenatal nutritional and DNA methylation. However, it remains unclear how common changes in DNA methylation are and whether they are sex- and timing-specific paralleling the later-life consequences of prenatal famine exposure. To this end, we investigated the methylation of 15 loci implicated in growth and metabolic disease in individuals who were prenatally exposed to a war-time famine in 1944-45. Methylation of INSIGF was lower among individuals who were periconceptionally exposed to the famine (n = 60) compared with their unexposed same-sex siblings (P = 2 x 10(-5)), whereas methylation of IL10, LEP, ABCA1, GNASAS and MEG3 was higher (all P < 10(-3)). A significant interaction with sex was observed for INSIGF, LEP and GNASAS. Next, methylation of eight representative loci was compared between 62 individuals exposed late in gestation and their unexposed siblings. Methylation was different for GNASAS (P = 1.1 x 10(-7)) and, in men, LEP (P = 0.017). Our data indicate that persistent changes in DNA methylation may be a common consequence of prenatal famine exposure and that these changes depend on the sex of the exposed individual and the gestational timing of the exposure.

Ideals' central tendency, and frequency of instantiation as determinants of graded structure in categories

Abstract: Three possible determinants of graded structure (typicality) were observed in common taxonomic categories and goal-derived categories: (1) an exemplar's similarity to ideals associated with goals its category serves; (2) an exemplar's similarity to the central tendency of its category (family resemblance); and (3) an exemplar's frequency of instantiation (people's subjective estimates of how often it is encountered as a category member) Experiment 1 found that central tendency did not predict graded structure in goal-derived categories, although it did predict graded structure in common taxonomic categories Ideals and frequency of instantiation predicted graded structure in both category types to sizeable and equal extents A fourth possible determinant--familiarity--did not predict typicality in either common taxonomic or goal-derived categories Experiment 2 demonstrated that both central tendency and ideals causally determine graded structure, and work showing that frequency causally determines graded structure is discussed Experiment 2 also demonstrated that the determinants of a particular category's graded structure can change with context Whereas ideals may determine a category's graded structure in one context, central tendency may determine a different graded structure in another It is proposed that graded structures do not reflect invariant structures associated with categories but instead reflect people's dynamic ability to construct concepts Language: en