Emory University

About: Emory University is a education organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 51959 authors who have published 122469 publications receiving 6010698 citations.

FMR1 protein: conserved RNP family domains and selective RNA binding

Abstract: Fragile X syndrome is the result of transcriptional suppression of the gene FMR1 as a result of a trinucleotide repeat expansion mutation. The normal function of the FMR1 protein (FMRP) and the mechanism by which its absence leads to mental retardation are unknown. Ribonucleoprotein particle (RNP) domains were identified within FMRP, and RNA was shown to bind in stoichiometric ratios, which suggests that there are two RNA binding sites per FMRP molecule. FMRP was able to bind to its own message with high affinity (dissociation constant = 5.7 nM) and interacted with approximately 4 percent of human fetal brain messages. The absence of the normal interaction of FMRP with a subset of RNA molecules might result in the pleiotropic phenotype associated with fragile X syndrome.

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients.

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness. People infected with this highly contagious virus can present with clinically inapparent, mild, or severe disease. Currently, the virus infection in individuals and at the population level is being monitored by PCR testing of symptomatic patients for the presence of viral RNA. There is an urgent need for SARS-CoV-2 serologic tests to identify all infected individuals, irrespective of clinical symptoms, to conduct surveillance and implement strategies to contain spread. As the receptor binding domain (RBD) of the spike protein is poorly conserved between SARS-CoVs and other pathogenic human coronaviruses, the RBD represents a promising antigen for detecting CoV-specific antibodies in people. Here we use a large panel of human sera (63 SARS-CoV-2 patients and 71 control subjects) and hyperimmune sera from animals exposed to zoonotic CoVs to evaluate RBD's performance as an antigen for reliable detection of SARS-CoV-2-specific antibodies. By day 9 after the onset of symptoms, the recombinant SARS-CoV-2 RBD antigen was highly sensitive (98%) and specific (100%) for antibodies induced by SARS-CoVs. We observed a strong correlation between levels of RBD binding antibodies and SARS-CoV-2 neutralizing antibodies in patients. Our results, which reveal the early kinetics of SARS-CoV-2 antibody responses, support using the RBD antigen in serological diagnostic assays and RBD-specific antibody levels as a correlate of SARS-CoV-2 neutralizing antibodies in people.

Elections Under Authoritarianism

Abstract: Current scholarship on elections in authoritarian regimes has focused on exploring the relationship between elections and democratization, and it has generally used analytical frameworks and methods imported from the study of genuinely democratic elections to do so. These tendencies have kept scholars from asking a wide range of questions about the micro-level dynamics of authoritarian elections and the systematic differences among them. With these issues in mind, this review examines literature that investigates the purpose of elections in dictatorships; the electoral behavior of voters, candidates, and incumbents in these elections; and the link between elections and democratization. The review ends with a call to redirect the study of authoritarian elections toward uncovering and explaining the important differences among them.

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

Abstract: Haydeh Payami and colleagues report results of a genome-wide association study for Parkinson's disease. They identify common variants in the HLA region associated with the late-onset sporadic form of the disease and replicate published associations with SNCA, MAPT and GAK.

Situated Simulation in the Human Conceptual System.

Abstract: Four theories of the human conceptual system—semantic memory, exemplar models, feed‐forward connectionist nets, and situated simulation theory—are characterised and contrasted on five dimensions: (1) architecture (modular vs. non‐modular), (2) representation (amodal vs. modal), (3) abstraction (decontextualised vs. situated), (4) stability (stable vs. dynamical), and (5) organisation (taxonomic vs. action–environment interface). Empirical evidence is then reviewed for the situated simulation theory, and the following conclusions are reached. Because the conceptual system shares mechanisms with perception and action, it is non-modular. As a result, conceptual representations are multi-modal simulations distributed across modality‐specific systems. A given simulation for a concept is situated, preparing an agent for situated action with a particular instance, in a particular setting. Because a concept delivers diverse simulations that prepare agents for action in many different situations, it is dynamical. ...