Institution
Indian Institute of Technology Bhubaneswar
Education•Bhubaneswar, India•
About: Indian Institute of Technology Bhubaneswar is a education organization based out in Bhubaneswar, India. It is known for research contribution in the topics: Large Hadron Collider & Computer science. The organization has 1185 authors who have published 3132 publications receiving 48832 citations.
Papers
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TL;DR: The data suggest that MGO-modification of the conserved R12 in αA-crystallin to hydroimidazolone may play an important role in reducing protein aggregation in the lens during aging and cataract formation.
Abstract: Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modification of αA-crystallin increased its chaperone function. We identified MGO-modified arginine residues in αA-crystallin and found that replacing such arginine residues with alanine residues mimicked the effects of MGO on the chaperone function. Arginine 12 (R12) is a conserved amino acid residue in Hsp27 as well as αA- and αB-crystallin. When treated with MGO at or near physiological concentrations (2–10 µM), R12 was modified to hydroimidazolone in all three small heat shock proteins. In this study, we determined the effect of arginine substitution with alanine at position 12 (R12A to mimic MGO modification) on the structure and chaperone function of these proteins. Among the three proteins, the R12A mutation improved the chaperone function of only αA-crystallin. This enhancement in the chaperone function was accompanied by subtle changes in the tertiary structure, which increased the thermodynamic stability of αA-crystallin. This mutation induced the exposure of additional client protein binding sites on αA-crystallin. Altogether, our data suggest that MGO-modification of the conserved R12 in αA-crystallin to hydroimidazolone may play an important role in reducing protein aggregation in the lens during aging and cataract formation.
41 citations
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TL;DR: It is indicated that incorporation of earthworms into the soil biofilter can reduce the degree of bio-clogging and might provide a highly sustainable, low cost and efficient treatment system for the developing countries.
41 citations
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TL;DR: The interference data exhibited that GNB is highly selective to DA even in the presence of common interfering species like ascorbic acid, uric Acid, glucose and lactic acid.
Abstract: In the present study, we report the electrochemical sensing property of multi-layer graphene nanobelts (GNBs) towards dopamine (DA). GNBs are synthesized from natural graphite and characterized by using techniques like field-emission scanning electron microscopy, atomic force microscopy and Raman spectroscopy. An electrochemical sensor based on GNBs is developed for the detection of DA. From the cyclic voltammetry and amperometry studies, it is found that GNBs possess excellent electrocatalytic activity towards DA molecules. The developed DA sensor showed a sensitivity value of 0.95 μA μM(-1) cm(-2) with a linear range of 2 μM to 0.2 mM. The interference data exhibited that GNB is highly selective to DA even in the presence of common interfering species like ascorbic acid, uric acid, glucose and lactic acid.
41 citations
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TL;DR: In this paper, a data-mining model based adaptive protection scheme was proposed to enhance distance relay performance during power swing for both compensated and uncompensated power transmission networks, where the proposed scheme is able to distinguish power swings and faults in series compensated power transmission network during stress condition like power swing.
41 citations
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TL;DR: In this paper, the authors reported high performance IR photocurrent response of two-dimensional hybrid materials consisting of layered WS2 nanosheets and reduced graphene oxide (RGO).
Abstract: We report high performance IR photocurrent response of two-dimensional hybrid materials consisting of layered WS2 nanosheets and reduced graphene oxide (RGO). Comparative photocurrent response studies of WS2 nanosheets, RGO, and WS2/RGO hybrids were carried out by performing current-voltage (I-V) and time-dependent current measurements with a laser excitation source having a wavelength of 808 nm. The experimental investigations indicate that WS2/RGO hybrids show negative photocurrent response, whereas WS2 and RGO show positive photocurrent response. The negative photocurrent response of the WS2/RGO hybrids is explained using a band alignment diagram and attributed to a charge transfer mechanism between WS2 and RGO. This analysis is further corroborated by first-principles density functional calculations. The fabricated device based on WS2/RGO hybrids shows a photosensitivity Rλ of about 6 AW−1 and a quantum efficiency η of ∼924%, which demonstrates high sensitivity of the hybrid material towards IR detect...
41 citations
Authors
Showing all 1220 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gabor Istvan Veres | 135 | 1349 | 96104 |
Márton Bartók | 76 | 622 | 26762 |
Kulamani Parida | 70 | 469 | 19139 |
Seema Bahinipati | 65 | 526 | 19144 |
Deepak Kumar Sahoo | 62 | 438 | 17308 |
Krishna R. Reddy | 58 | 400 | 11076 |
Ramayya Krishnan | 52 | 195 | 10378 |
Saroj K. Nayak | 49 | 149 | 8319 |
Dipak Kumar Sahoo | 47 | 234 | 7293 |
Ganapati Panda | 46 | 356 | 8888 |
Raj Kishore | 45 | 149 | 6886 |
Sukumar Mishra | 44 | 405 | 7905 |
Mar Barrio Luna | 43 | 179 | 5248 |
Chandra Sekhar Rout | 41 | 183 | 7736 |
Subhransu Ranjan Samantaray | 39 | 167 | 4880 |