Indian Institute of Technology Kharagpur

About: Indian Institute of Technology Kharagpur is a education organization based out in Kharagpur, India. It is known for research contribution in the topics: Computer science & Dielectric. The organization has 16887 authors who have published 38658 publications receiving 714526 citations.

An efficient algorithm to solve integer-programming problems arising in system-reliability design

Abstract: A simple and efficient technique for solving integer-programming problems that normally arise in system-reliability design is introduced. It quickly solves even a very large system problem. It consists of a systematic search near the boundary of constraints and involves functional evaluations only. It can handle system-reliability design problems of any type in which the decision variables are restricted to integer values. Several illustrative examples are given to substantiate these assertions. >

Criticality Assessment Models for Failure Mode Effects and Criticality Analysis Using Fuzzy Logic

Abstract: Traditional Failure Mode and Effects Analysis (FMEA) has shown its effectiveness in defining, identifying, and eliminating known and/or potential failures or problems in products, process, designs, and services to help ensure the safety and reliability of systems applied in a wide range of industries. However, its approach to prioritize failure modes through a crisp risk priority number (RPN) has been highly controversial. This paper proposes two models for prioritizing failures modes, specifically intended to overcome such limitations of traditional FMEA. The first proposed model treats the three risk factors as fuzzy linguistic variables, and employs alpha level sets to provide a fuzzy RPN. The second model employs an approach based on the degree of match and fuzzy rule-base. This second model considers the diversity and uncertainty in the opinions of FMEA team members, and converts the assessed information into a convex normalized fuzzy number. The degree of match (DM) is used thereafter to estimate the matching between the assessed information and the fuzzy number characterizing the linguistic terms. The proposed models are suitably supplemented by illustrative examples.

Chemical Reactivity and Selectivity: Local HSAB Principle versus Frontier Orbital Theory

Abstract: It has been argued that the maximum Fukui function site is the best for the frontier-controlled soft−soft reactions whereas for the charge-controlled hard−hard interactions the preferred site is associated with the maximum net charge and not necessarily the minimum Fukui function.

Thermal and pH Responsive Polymer-Tethered Multifunctional Magnetic Nanoparticles for Targeted Delivery of Anticancer Drug

Abstract: Targeted and efficient delivery of therapeutics to tumor cells is one of the key issues in cancer therapy. In the present work, we report a temperature and pH dual responsive core–shell nanoparticles comprising smart polymer shell coated on magnetic nanoparticles as an anticancer drug carrier and cancer cell-specific targeting agent. Magnetite nanoparticles (MNPs), prepared by a simple coprecipitation method, was surface modified by introducing amine groups using 3-aminopropyltriethoxysilane. Dual-responsive poly(N-isopropylacrylamide)-block-poly(acrylic acid) copolymer, synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization, was then attached to the amine-functionalized MNPs via EDC/NHS method. Further, to accomplish cancer-specific targeting properties, folic acid was tethered to the surface of the nanoparticles. Thereafter, rhodamine B isothiocyanate was conjugated to endow fluorescent property to the MNPs required for cellular imaging applications. The nanoparticles were...