Jodhpur National University

About: Jodhpur National University is a education organization based out in Jodhpur, India. It is known for research contribution in the topics: Transdermal & Self-healing hydrogels. The organization has 160 authors who have published 216 publications receiving 2381 citations.

Chebulic acid attenuates ischemia reperfusion induced biochemical alteration in diabetic rats.

Abstract: Context: Diabetic nephropathy is one of the important microvascular complications of diabetes; however, the main problem remains is the control of progression of nephropathy in diabetes. Chebulic acid was selected, as tannins from Terminalia chebula are used as antidiabetic, renoprotective, antioxidant, hypotensive and an α-glucosidase inhibitor.Objective: In this study, we evaluated the effect of chebulic acid on ischemia reperfusion induced biochemical alteration in diabetic rats.Materials and methods: Chebulic acid (CA) was isolated from T. chebula; LD50 and acute toxicity studies of CA were done. Renal ischemia and reperfusion technique was used to induce nephropathy in diabetic rats. Glibenclamide (10 mg/kg) was used as diabetic standard; CA at doses of 25 and 50 mg/kg were administered for 28 days and various biochemical parameters were monitored.Results: The LD50 was found to be 251 mg/kg; 25 and 50 mg/kg doses were selected as no toxic symptoms were observed at both doses, except slight diarrhea. ...

Evaluation of in-vitro anti-oxidant and free radical scavenging activities of Withania somnifera and Aloe vera.

Abstract: In this study, In-vitro Antioxidant and free radical scavenging activity of Withania somnifera (WS) and Aloe vera (AV) extract were evaluated in series of in vitro assays. Anti-oxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. In this present study we investigated anti-oxidant and free radical scavenging activity of Withania somnifera and Aloe vera by Hydroxyl radical scavenging activity, Hydrogen peroxide-scavenging assay, Super oxide scavenging activity, Reducing power, Chelating capacity, Total antioxidant activity. The results showed that both the plant possesses excellent anti-oxidant and free radical scavenging activity. Screening of both the plant at different doses (100, 150 and 200 μg/ml) help to reveal the potential of individual plants. Withania somnifera shown better hydroxyl radical scavenging activity, reducing power and superoxide radical scavenging activity compare to Aloe vera. While Aloe vera possesses better chelating power then Withania somnifera. Both the plant possesses almost equivalent hydrogen peroxide scavenging activity while the total antioxidant capacity was found much better in Withania somnifera as compare to Aloe vera. The antioxidant activity of both the plant might be attributed to its polyphenolic content and other phytochemicals constituents. The findings of the present study suggest that all extracts could be a potential source of natural antioxidant that could have great importance as therapeutic agents.

Impact of a modified carbonated beverage on human dental plaque and salivary pH: an in vivo study.

Abstract: Background: To assess the plaque and salivary pH changes at different time intervals in vivo after consumption of a carbonated beverage modified with sodium fluoride and calcium phosphate Materials and Methods: Twenty-four subjects aged 18-25 years were recruited and randomly assigned to three groups (group A, original drink sprite; group B, sprite with sodium fluoride; group C, sprite with calcium phosphate) Collection of pooled plaque and unstimulated saliva was done before and after the drinks were consumed by the subjects at 5-, 10-, 20- and 30-minute intervals Results: The pH rise was higher with group C for plaque and group B for saliva Conclusions: Modification of the test carbonated beverage with calcium phosphate and fluoride may exert some protective potential, especially in high caries risk candidates

Formulation and characterization of liquisolid tablets of valsartan for improvement of dissolution rate

Abstract: Objective: The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The objective of this study is to screening of non-volatile solvent in which drug shows maximum solubility and then formulation of different liquisolid (LS) compacts using mathematical equations to increase the dissolution rate of drug. Materials and Methods: Different LS compacts were prepared using a mathematical model for calculating required quantities of powder and liquid ingredients to produce an acceptably flowable and compressible admixture. Avicel PH 102, aerosil 200 and crospovidone were employed as a carrier, coating material and disintegrant, respectively. The prepared LS systems were evaluated for their flow behavior and possible drugexcipient interactions by infrared (IR) spectra analysis and X-ray diffraction (XRD). Morphological changes in the final formulation were investigated by scanning electron microscopy (SEM), liquisolid compacts were prepared and evaluated for their tableting properties. Results: Valsartan shows maximum solubility in propylene glycol a non-volatile solvent. The IR studies ruled out any significant interaction between the drug and excipients. The XRD analysis confirmed formation of a solid solution inside the compact matrix. SEM indicates that the drug was totally solubilized in the LS system. The tableting properties of the LS compacts were within the acceptable limits. The release rates of LS compacts were markedly higher compared with directly compressed tablets due to increasing wetting properties and surface area of the drug. Conclusion: This study shows that the LS technique is a promising alternative tool for improvement of the dissolution rate of biopharmaceutical classification system Class II drug. Keywords: Dissolution rate, Liquisolid compact, Valsartan, Non-volatile solvents, Liquid load factor