Institution
Jodhpur National University
Education•Jodhpur, India•
About: Jodhpur National University is a education organization based out in Jodhpur, India. It is known for research contribution in the topics: Transdermal & Self-healing hydrogels. The organization has 160 authors who have published 216 publications receiving 2381 citations.
Topics: Transdermal, Self-healing hydrogels, Swelling, Chitosan, Population
Papers
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TL;DR: It is indicated that recurrent aphthous ulceration is a common mucosal disorder in the Indian population and the early and proper diagnosis of the ulcers will help the dental practitioner in providing information to the patient regarding awareness and management of the condition.
Abstract: Objective: Patients with an oral ulcer may present initially to a general physician or a dental practitioner. Majority of the ulcers are benign and resolve spontaneously but small proportions are malignant. The aim of the present study was to determine the prevalence of recurrent aphthous ulcerations in the Indian population. Material and Methods: 3244 patients attending the Department of Oral Medicine and Radiology during the period from November, 2010 to December, 2012 with various complaints were examined. Of the patients examined 1669 were females and 1575 were males. Results: 705 patients presented with recurrent aphthous ulceration (21.7%). Females (56.3%) were more commonly affected than males (43.7%). Patients in the third and fourth decade were most commonly affected. Stress was the most common factor associated with recurrent aphthous stomatitis (386 patients). 54.5% patients did not take any medications and 72.9% patients opined that the condition needed no dental consultation. Conclusion: The results of the present study indicate that recurrent aphthous ulceration is a common mucosal disorder in the Indian population. The early and proper diagnosis of the ulcers will help the dental practitioner in providing information to the patient regarding awareness and management of the condition.
49 citations
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TL;DR: The results of study suggest that semi-IPNs of chitosan/PVP are potent candidates for delivery of clarithromycin in acidic environment.
Abstract: The aim of this study was to develop a pH-sensitive chitosan/polyvinyl pyrrolidone (PVP) based controlled drug release system for clarithromycin. The hydrogels were synthesized by cross-linking chitosan and PVP blend with glutaraldehyde to form a semi-interpenetrating polymer network (semi-IPN). These semi-IPNs were studied for their content uniformity, swelling index (SI), mucoadhesion, wettability, in vitro release and their release kinetics. The hydrogels showed more than 97% content of clarithromycin. These hydrogels showed high swelling and mucoadhesion under acidic conditions. The swelling may be due to the protonation of a primary amino group on chitosan. In acidic condition, chitosan would be ionized, and adhesion could have occurred between the positively charged chitosan and the negatively charged mucus. In the alkaline condition, less swelling and mucoadhesion was noticed. In vitro release study revealed that formulation containing chitosan (2% w/v) and PVP (4% w/v) in the ratio of 21:4 showed complete drug release after 12 h. Release profile showed that all the formulations followed non-Fickian diffusion mechanism. The cross-linking and compatibility of clarithromycin in the formulation was studied by Fourier transform infrared (FTIR) spectroscopic analysis, differential scanning calorimetry (DSC) and powder X-ray diffraction (p-XRD) study, which confirmed proper formation of semi-IPN and stability of clarithromycin in the formulations. The surface morphology of semi-IPN was studied before and after dissolution in simulated gastric fluid (SGF, pH 1.2) which revealed pores formation in membrane after dissolution. The results of study suggest that semi-IPNs of chitosan/PVP are potent candidates for delivery of clarithromycin in acidic environment.
47 citations
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TL;DR: In this paper, Caralluma fimbriata extract induced simple single step green synthesis of pure and Gd loaded ZnO nanostructures towards the improvement of photocatalytic performance under both UV and Sunlight irradiation.
42 citations
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TL;DR: It can be concluded that the R. ellipticus fruits could be pharmaceutically exploited for antioxidant properties at concentration-dependent manner.
Abstract: Various studies have been done to identify antioxidants from plant sources and efforts have been taken to incorporate it in conventional therapy. In our present study, petroleum ether, ethanolic, and aqueous extracts of Rubus ellipticus fruits have been evaluated for in vitro antioxidant activity using DPPH radical scavenging and reducing power assay. BHA was used as a standard antioxidant for DPPH radical scavenging activity. The reducing power assay of extracts was carried out with ascorbic acid as a standard reducing agent. All the analysis was made with the use of UV-Visible spectrophotometer. The results of the both assay showed that all the extracts of R. ellipticus fruits possess significant free radical scavenging and reducing power properties at concentration-dependent manner. Hence, it can be concluded that the R. ellipticus fruits could be pharmaceutically exploited for antioxidant properties.
42 citations
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TL;DR: Findings provide experimental evidence that the combination of allopathic hypoglycemic drugs withhypoglycemic Polyherbal formulations provides effective and rapid glycemic control and can also minimize the cardiovascular risk factors of type II diabetes mellitus.
40 citations
Authors
Showing all 162 results
Name | H-index | Papers | Citations |
---|---|---|---|
Aftab Ahmad | 44 | 375 | 7413 |
Chirag P. Shah | 24 | 71 | 2081 |
Rajesh Kumar | 16 | 56 | 702 |
Santosh Patil | 16 | 108 | 913 |
Anil Bhandari | 14 | 96 | 702 |
Ashish Sharma | 14 | 108 | 841 |
Praveen Kumar Gaur | 13 | 38 | 539 |
Sanjay Sharma | 13 | 45 | 542 |
Subhash S. Vaghani | 11 | 17 | 424 |
Sneha Maheshwari | 10 | 23 | 300 |
Suresh Purohit | 10 | 39 | 359 |
Jitendra Vaghasiya | 10 | 22 | 347 |
Sumita Kaswan | 9 | 11 | 223 |
N. P. Jivani | 9 | 25 | 253 |
Yagnik Bhalodia | 9 | 20 | 308 |