Jodhpur National University

About: Jodhpur National University is a education organization based out in Jodhpur, India. It is known for research contribution in the topics: Transdermal & Self-healing hydrogels. The organization has 160 authors who have published 216 publications receiving 2381 citations.

A Proposed Methodology for In Vitro Evaluation of Bitterness in Drug Solutions and In Vitro Drug Release Samples

Abstract: Purpose Ethical and safety concerns, paediatric taste panels and predictivity in early drug development for strategic decisions are some of the reasons for seeking in vitro methods of bitterness evaluation for drugs and drug products. In this study, taste panel studies and in vitro drug release studies have been performed, correlated to each other and proposed as an analytical tool for evaluation of bitterness.

Micronuclei frequencies and nuclear abnormalities in oral exfoliated cells of nuclear power plant workers.

Abstract: Aim : Biomonitoring provides a useful tool to estimate the genetic risk fromexposure to genotoxic agents. The aim of this study was to evaluate the frequencies of Micronuclei (MN) and other Nuclear abnormalities (NA) from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers. Material & methods: Micronucleus frequencies in oral exfoliated cells were done from individuals not known to be exposed to either environmental or occupational carcinogens(Group I). Similarly samples were obtained from full-time Nuclear Power Station (NPS) workerswith absence of Leukemia and any malignancy(Group II) and workers diagnosed as leukemic patients and undergoing treatment (Group III). results : There was statistically significant difference between Group I, Group II & Group III. MN and NA frequencies in Leukemic Patientswere significantly higher than those in exposed workers &control groups (p < 0.05). conclusion : MN and other NA reflect genetic changes, events associated with malignancies. Therefore, there is aneed to educate those who work in NPS about the potential hazard ofoccupational exposure and the importance of using protective measures.(KL) and broken egg (BE) with MN provide a more comprehensive assessment of genome damage then only MN [4,5]. Hence, the present study evaluated the frequencies of micronuclei and other metanucleated abnormalities from exfoliated oral mucosal cells in Nuclear Power Station (NPS) workers.

Secure Neighbor Discovery (SEND) Protocol challenges and approaches

Abstract: Internet Protocol version 6 (IPv6) was standardized more than a decade and a half ago even then the security associations has not yet gained its momentum. IPv6 nodes use the Neighbor Discovery Protocol (NDP) to discover other link local address on the link, NDP covers host initialization and address auto configuration. IPv6 mandates to support Internet Protocol Security (IPSec). However, this security protocol does not cover the link local communication that uses neighbor discovery. NDP is vulnerable to various attacks when it is not secured and impractical due to the very large number of manually configured security associations needed for protecting NDP. For this reason, RFC 3971, the SEcure Neighbor Discovery (SEND) Protocol was proposed. SEND is a Strong security mechanism that can make the IPv6 link-local communication very safe. Although the SEND is considered to be a promising solution with which to protect NDP and to make IPv6 a very secure protocol, the deployment is not easy and thus very challenging. This paper propose performance analysis and comparison framework for SEND functionalities, discuss the practical consideration and approaches of SEND deployment in securing IPv6 network.

A general overview of gingiva

Abstract: The gingiva (gum) is the protective type of skin that is closely adapted to the necks of the teeth and covers the bone holding the roots of the teeth. Healthy gingiva is usually coral pink, but may contain physiologic pigmentation. Changes in color, particularly increased redness, together with edema and an increased tendency to bleed, suggest an inflammation that is possibly due to the accumulation of bacterial plaque. This article throws light on the types of gingiva, different cells present in gingiva, gingival disease etc. A review of some patents on gingiva is also provided that summarizes the recent advancements taken place in this area.

Enhancement of Transdermal Permeation of Indinavir Sulfate via EthosomeVesicles

Abstract: The aim of the present study is to investigate the potential of ethosomal formulations for transdermal delivery of indinavir sulphate from ethosomes. Vesicles containing phosphatidylcholine mixed with ethanol and indinavir sulphate were prepared by conventional mechanical stirrer method and characterized by various parameters (vesicles shape and surface morphology, size and size distribution, entrapment efficiency, elasticity, turbidity and in vitro drug release). The effect of different formulation variable on skin permeation of indinavir sulphate was studied via synthetic semipermeable membrane or skin of new born mice by using diffusion cell. The selected system were incorporated into carbopol 934P gel and evaluated for both drug permeation and mice skin deposition. The optimized ethosomal formulation showed transdermal flux of 25.01±0.34 μg/cm2 /h across rat skin as compared to 2.98±0.21μg/cm2 /h for plane drug solution, 4.28±0.54 μg/cm2 /h for hydroethanolic solution and 9.7±0/21 μg/cm2 /h for classical liposomes. The obtained flux was nearly 7.5 and 12.04 times higher than conventional liposomal formulation bearing indinavir sulphate and plain drug solution. These results suggest that ethosomes are potential vehicles for improved transdermal delivery of indinavir sulphate.