Kettering University

About: Kettering University is a education organization based out in Flint, Michigan, United States. It is known for research contribution in the topics: Cancer & RNA. The organization has 6842 authors who have published 7689 publications receiving 337503 citations. The organization is also known as: GMI Engineering & Management Institute & General Motors Institute.

Acoustic monopoles, dipoles, and quadrupoles: An experiment revisited

Abstract: A simple and inexpensive demonstration of acoustic monopole, dipole, and quadrupole sources utilizes four 4-in. boxed loudspeakers and a homemade switch box. The switch box allows the speakers to be driven in any combination of phase relationships. Placing the speakers on a rotating stool allows students to measure directivity patterns for monopole, dipole, and quadrupole speaker combinations. Stacking the speakers in a square, all facing the same direction, allows students to aurally compare the frequency and amplitude dependence of sound radiation from monopoles, dipoles, and quadrupoles.

Cross-linking of Deoxyribonucleic Acid to Protein following Ultra-Violet Irradiation of Different Cells

Abstract: Ultraviolet radiation effects on DNA when irradiated as a nucleo-protein inside cells were found to be qualitatively and quantitatively different from those that are produced when pure DNA is treated. The test used for the detection of crosslinks between DNA helices was the formation of an insoluble gel network. When the DNA was isolated from sperm cells by standard deproteinization procedures, the amount recovered decreased markedly on irradiation. Some of the DNA from the irradiated cells was found in the insoluble protein fraction, instead of in the supernatant. This is assumed to be due to the fact that protein became covalently linked to the DNA and that this complex travels with the protein fraction during the separation procedure. It is suggested that protein linking to DNA may contribute significantly to the killing of cells by ultraviolet light, since the reaction is readily detectable by physico-chemical methods with amounts of radistion that are necessary for killing 99.9% of the cells, and smaller doses are therefore likely to alter biologically significant amounts of DNA. (P.C.H.)

A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides

Abstract: We describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles.