Kettering University

About: Kettering University is a education organization based out in Flint, Michigan, United States. It is known for research contribution in the topics: Cancer & RNA. The organization has 6842 authors who have published 7689 publications receiving 337503 citations. The organization is also known as: GMI Engineering & Management Institute & General Motors Institute.

Genetics of natural resistance to herpesvirus infections in mice.

Abstract: INHERITED resistance to virus infections has been demonstrated in several murine systems1–6. Susceptibility to mouse hepatitis virus3 and resistance to arbovirus7 infections in mice are dominant traits associated with the capacity of macrophages from the susceptible strains to replicate virus. Resistance to Friend leukaemia virus- and Gross leukaemia virus-induced leukaemogenesis is determined by at least two genes, one closely linked to the immune response genes of the mouse8. Conversely, susceptibility to lymphocytic choriomeningitis (LCM) virus infections in mice has been associated with a gene closely linked to the immune response genes9. The latter seems to be associated with the cell-mediated immune response to LCM which causes tissue damage and leads to death. Cell-mediated immunity seems to be important in resistance against herpes simplex virus (HSV) infections10–12. Analysis of the aspects of cell-mediated immunity which might be involved in resistance in man is complicated by the uncontrollable factors associated with activation of latent herpesvirus infections. I have developed a mouse model which has shown that at least three genes are responsible for resistance to HSV. Although preliminary evidence suggests that resistance is immunologically mediated, resistance genes do not seem to be closely linked to the histocompatibility region of the mouse.

Neural transplantation for the treatment of Parkinson's disease.

Abstract: trials showed unequivocally that human fetal dopaminergicneurons can survive and function for more than 10 years inthe striatum of patients with PD and show no signs of beingaffected by the ongoing disease process. These studies have also provided a clear indication that grafted fetaldopaminergic neurons can be therapeutically effective. On thebasis of the limited, but encouraging, observations in theseearly open-label trials,

Fc receptors initiate the Arthus reaction: Redefining the inflammatory cascade

Abstract: Antibody-antigen complexes initiate the inflammatory response and are central to the pathogenesis of tissue injury. The classical model for this immunopathological cascade, the Arthus reaction, was reinvestigated with a murine strain deficient in Fc receptor expression. Despite normal inflammatory responses to other stimuli, the inflammatory response to immune complexes was markedly attenuated. These results suggest that immune complex-triggered inflammation is initiated by cell bound Fc receptors and is then amplified by cellular mediators and activated complement. These results redefine the inflammatory cascade and may offer other approaches for the study and treatment of immunological injury.

Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum.

Abstract: The most noticeable morphological feature of the cerebellum is its folded appearance, whereby fissures separate its anterior-posterior extent into lobules. Each lobule is molecularly coded along the medial-lateral axis by parasagittal stripes of gene expression in one cell type, the Purkinje cells (PCs). Additionally, within each lobule distinct combinations of afferents terminate and supply the cerebellum with synchronized sensory and motor information. Strikingly, afferent terminal fields are organized into parasagittal domains, and this pattern bears a close relationship to PC molecular coding. Thus, cerebellum three-dimensional complexity obeys a basic coordinate system that can be broken down into morphology and molecular coding. In this review, we summarize the sequential stages of cerebellum development that produce its laminar structure, foliation, and molecular organization. We also introduce genes that regulate morphology and molecular coding, and discuss the establishment of topographical circuits within the context of the two coordinate systems. Finally, we discuss how abnormal cerebellar organization may result in neurological disorders like autism.