Kyungpook National University

About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.

Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model.

Abstract: Proinflammatory mediators, such as tumor necrosis factor (TNF) alpha, interleukin (IL)-1beta and IL-6 have been found to play a key role in the propagation of persistent pain states. We investigated the temporal expressions of the mRNAs and the receptor mRNAs of TNFalpha, IL-1beta and IL-6 in rat dorsal root ganglia and spinal cord in a chronic constriction injury model of neuropathic pain. Our results show that the maximal induction of IL-6 mRNA occurred later and was more sustained than those of TNFalpha and IL-1beta mRNAs in the dorsal root ganglia and spinal cord following chronic injury. Receptors mRNAs, except TNF receptor 2 and gp130 mRNAs, showed temporal profiles that were similar to those of their cytokine mRNAs. Additionally, the induction of the mRNAs of cytokines and of their receptors in the dorsal root ganglia was more rapid than in the spinal cord.

Core-like groups result in invalidation of identifying super-spreader by k-shell decomposition

Abstract: Identifying the most influential spreaders is an important issue in understanding and controlling spreading processes on complex networks. Recent studies showed that nodes located in the core of a network as identified by the k-shell decomposition are the most influential spreaders. However, through a great deal of numerical simulations, we observe that not in all real networks do nodes in high shells are very influential: in some networks the core nodes are the most influential which we call true core, while in others nodes in high shells, even the innermost core, are not good spreaders which we call core-like group. By analyzing the k-core structure of the networks, we find that the true core of a network links diversely to the shells of the network, while the core-like group links very locally within the group. For nodes in the core-like group, the k-shell index cannot reflect their location importance in the network. We further introduce a measure based on the link diversity of shells to effectively distinguish the true core and core-like group, and identify core-like groups throughout the networks. Our findings help to better understand the structural features of real networks and influential nodes.

Plant growth promoting endophytic fungi Asprgillus fumigatus TS1 and Fusarium proliferatum BRL1 produce gibberellins and regulates plant endogenous hormones

Abstract: Endophytes can serve as plant growth promoters as they secret a vast array of phytohormones to support host plants. Keeping the growth promoting activity of the endophytes in view, two endophytic fungi, Asprgillus fumigatus TS1 and Fusarium proliferatum BRL1 have been isolated from the roots of Oxalis corniculata. The isolates have been screened initially for growth promoting activities, including siderophores activity, phosphate solubilization, and secreation of indole acetic acid and gibberellins. Further, the isolates have assayed for the ability to promote the growth of mutant rice Waito-C. The plants associated with TS1 and BRL1 have shown higher chlorophyll content, root-shoot length, and biomass production. The growth promoting activity of the endophytes can be attributed to the various types of GAs and IAA that have been observed in the culture filtrates of the endophytes by the Gas chromatography/mass spectrometry (GC/MS). The GC/MS analysis revealed the presence of different gibberellins concentrations (ng/ml) in TS1 and BRL1 culture filtrate, i.e. GA1 (0.091 ± 0.009, 0.392 ± 0.007), GA3 (0.324 ± 0.077, 0.089 ± 0.0007) and GA7 (0.023 ± 0.002, 0.492 ± 0.005), respectively. Besides, a significant up regulation of plant endogenous GA1 (12.443 ± 0.454 and 15.434 ± 0.245) has been obsereved in TS1 and BRL1 associated plants compared to the control. Moreover, semi quantitative RT-PCR has confirmed the presence/invovment of GA pathways genes (P50–1, P450–3, P450–4, ggs2, and des). The results conclude that the endophytes isolated in this study can ably synthesize bioactive compounds, which play an important role in plant growth promotion.