Institution
Kyungpook National University
Education•Daegu, South Korea•
About: Kyungpook National University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Population & Catalysis. The organization has 20497 authors who have published 42107 publications receiving 834608 citations.
Topics: Population, Catalysis, Large Hadron Collider, Adsorption, Medicine
Papers published on a yearly basis
Papers
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TL;DR: The development of new nanoscale drug carriers, chitosan-based nanoparticles (CNPs) that could encapsulate a photosensitizer, protophorphyrin IX (PpIX), and deliver it to tumor tissue and results indicate that PpIX-CNPs have potential as an effective drug delivery system for clinical photodynamic therapy.
154 citations
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TL;DR: It is shown that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling, and this results suggest that the antioxidant effect of PPARγ is exclusively mediated by GPx3 and further imply that GP x3 may be a therapeutic target for insulin resistance and diabetes mellitus.
Abstract: Oxidative stress plays an important role in the pathogenesis of insulin resistance and type 2 diabetes mellitus and in diabetic vascular complications. Thiazolidinediones (TZDs), a class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, improve insulin sensitivity and are currently used for the treatment of type 2 diabetes mellitus. Here, we show that TZD prevents oxidative stress-induced insulin resistance in human skeletal muscle cells, as indicated by the increase in insulin-stimulated glucose uptake and insulin signaling. Importantly, TZD-mediated activation of PPARgamma induces gene expression of glutathione peroxidase 3 (GPx3), which reduces extracellular H(2)O(2) levels causing insulin resistance in skeletal muscle cells. Inhibition of GPx3 expression prevents the antioxidant effects of TZDs on insulin action in oxidative stress-induced insulin-resistant cells, suggesting that GPx3 is required for the regulation of PPARgamma-mediated antioxidant effects. Furthermore, reduced plasma GPx3 levels were found in patients with type 2 diabetes mellitus and in db/db/DIO mice. Collectively, these results suggest that the antioxidant effect of PPARgamma is exclusively mediated by GPx3 and further imply that GPx3 may be a therapeutic target for insulin resistance and diabetes mellitus.
154 citations
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University of Auckland1, University of Chieti-Pescara2, University of Southern California3, University of North Carolina at Chapel Hill4, Louisiana State University5, Kyungpook National University6, Pontifícia Universidade Católica de São Paulo7, University of Valladolid8, Carlos III Health Institute9, Harvard University10, Tufts University11, IMDEA12, Pontifical Catholic University of Chile13, Brigham and Women's Hospital14, National Autonomous University of Mexico15, University of Navarra16, International Union of Nutritional Sciences17
TL;DR: A scientific society, such as the International Society of Nutrigenetics/Nutrigenomics (ISNN), internationally devoted to the study of nutrigenetically-based studies can indeed serve the commendable roles of promoting science and favoring scientific communication and permanently working as a ‘clearing house' to prevent disqualifying logical jumps, correct or stop unwarranted claims, and prevent the creation of unwarranted expectations in patients and in the general public.
Abstract: Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition-related diseases. Current views on personalized nutrition encompass omics technologies (nutrigenomics, transcriptomics, epigenomics, foodomics, metabolomics, metagenomics, etc.), functional food development and challenges related to legal and ethical aspects, application in clinical practice, and population scope, in terms of guidelines and epidemiological factors. In this context, precision nutrition can be considered as occurring at three levels: (1) conventional nutrition based on general guidelines for population groups by age, gender and social determinants; (2) individualized nutrition that adds phenotypic information about the person's current nutritional status (e.g. anthropometry, biochemical and metabolic analysis, physical activity, among others), and (3) genotype-directed nutrition based on rare or common gene variation. Research and appropriate translation into medical practice and dietary recommendations must be based on a solid foundation of knowledge derived from studies on nutrigenetics and nutrigenomics. A scientific society, such as the International Society of Nutrigenetics/Nutrigenomics (ISNN), internationally devoted to the study of nutrigenetics/nutrigenomics, can indeed serve the commendable roles of (1) promoting science and favoring scientific communication and (2) permanently working as a 'clearing house' to prevent disqualifying logical jumps, correct or stop unwarranted claims, and prevent the creation of unwarranted expectations in patients and in the general public. In this statement, we are focusing on the scientific aspects of disciplines covering nutrigenetics and nutrigenomics issues. Genetic screening and the ethical, legal, social and economic aspects will be dealt with in subsequent statements of the Society.
154 citations
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TL;DR: P. spadiceum AGH786 boosted the NaCl stress tolerance and growth in soybean, by modulating seedlings endogenous phytohormones and isoflavones suggesting a valuable contribution of this potent fungal biofertilizer in sustainable agriculture in salt affected soils.
Abstract: In the pursuit of sustainable agriculture through environment and human health friendly practices, we evaluated the potential of a novel gibberellins (GAs) producing basidiomycetous endophytic fungus Porostereum spadiceum AGH786, for alleviating salt stress and promoting health benefits of soybean. Soybean seedlings exposed to different levels of NaCl stress (70 and 140 mM) under greenhouse conditions, were inoculated with the AGH786 strain. Levels of phytohormones including GAs, JA and ABA, and isoflavones were compared in control and the inoculated seedlings to understand the mechanism through which the stress is alleviated. Gibberellins producing endophytic fungi have been vital for promoting plant growth under normal and stress conditions. We report P. spadiceum AGH786 as the ever first GAs producing basidiomycetous fungus capable of producing six types of GAs. In comparison to the so for most efficient GAs producing Gibberella fujikuroi, AGH786 produced significantly higher amount of the bioactive GA3. Salt-stressed phenotype of soybean seedlings was characterized by low content of GAs and high amount of ABA and JA with reduced shoot length, biomass, leaf area, chlorophyll contents, and rate of photosynthesis. Mitigation of salt stress by AGH786 was always accompanied by high GAs, and low ABA and JA, suggesting that this endophytic fungus reduces the effect of salinity by modulating endogenous phytohormones of the seedlings. Additionally, this strain also enhanced the endogenous level of two isoflavones including daidzen and genistein in soybean seedlings under normal as well as salt stress conditions as compared to their respective controls. P. spadiceum AGH786 boosted the NaCl stress tolerance and growth in soybean, by modulating seedlings endogenous phytohormones and isoflavones suggesting a valuable contribution of this potent fungal biofertilizer in sustainable agriculture in salt affected soils.
154 citations
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TL;DR: In this paper, the authors measured spin transfer from circularly polarized real photons to recoiling hyperons using the CLAS detector at Jefferson Lab for center-of-mass energies between 1.6 and 2.53 GeV.
Abstract: Spin transfer from circularly polarized real photons to recoiling hyperons has been measured for the reactions $$\vec\gamma + p \to K^+ + \vec\Lambda$$ and $$\vec\gamma + p \to K^+ + \vec\Sigma^0$$. The data were obtained using the CLAS detector at Jefferson Lab for center-of-mass energies $W$ between 1.6 and 2.53 GeV, and for $$-0.85<\cos\theta_{K^+}^{c.m.}< +0.95$$. For the $$\Lambda$$, the polarization transfer coefficient along the photon momentum axis, $C_z$, was found to be near unity for a wide range of energy and kaon production angles. The associated transverse polarization coefficient, $C_x$, is smaller than $C_z$$ by a roughly constant difference of unity. Most significantly, the {\it total} $$\Lambda$ polarization vector, including the induced polarization $P$, has magnitude consistent with unity at all measured energies and production angles when the beam is fully polarized. For the $$\Sigma^0$$ this simple phenomenology does not hold. All existing hadrodynamic models are in poor agreement with these results.
153 citations
Authors
Showing all 20671 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
David R. Jacobs | 165 | 1262 | 113892 |
Yang Yang | 164 | 2704 | 144071 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
Inkyu Park | 144 | 1767 | 109433 |
Christopher George Tully | 142 | 1843 | 111669 |
Teruki Kamon | 142 | 2034 | 115633 |
Manfred Paulini | 141 | 1791 | 110930 |
Kazuhiko Hara | 141 | 1956 | 107697 |
Luca Lista | 140 | 2044 | 110645 |
Dong-Chul Son | 138 | 1370 | 98686 |
Christoph Paus | 137 | 1585 | 100801 |
Frank Filthaut | 135 | 1684 | 103590 |
Andreas Warburton | 135 | 1578 | 97496 |